2026-05-17T01:16:03Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/159282024-09-21T13:23:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Rubini-Costa, Ricardo author Bermúdez-Jiménez, Francisco author Rivera-López, Ricardo author Sola-García, Elena author Nagib-Raya, Hadi author Moreno-Escobar, Eduardo author López-Zúñiga, Miguel Ángel author Briones-Través, Adela author Sanz-Herrera, Francisco author Sequí-Sabater, Jose Miguel author Romero-Cabrera, Juan Luis author Maíllo-Seco, Javier author Fernández-Vázquez, Felipe author Rivadeneira-Ruiz, María author López-Valero, Lucas author Gómez-Navarro, Carlos author Aparicio-Gómez, Jose Antonio author López, Miguel Álvarez author Tercedor, Luis author Molina-Jiménez, María author Macías-Ruiz, Rosa author Jiménez-Jáimez, Juan author 2022-06-24 Atrial fibrillation (AF) is common in patients admitted with severe COVID-19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19. We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleeding, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death. 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%), p=0.003; 52 (34.4%) vs 35 (23.2%), p=0.03, respectively]. The multivariate analysis showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as independent predictor of in-hospital major bleeding. AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk. Med Clin (Barc). 2022 Jun 24;158(12):569-575. 10.1016/j.medcli.2021.06.015 1578-8989 Medicina clinica 34364707 http://hdl.handle.net/20.500.12105/15928 Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection.