2026-04-27T03:43:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159232024-09-27T08:52:48Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Quail, Daniela F
author
Amulic, Borko
author
Aziz, Monowar
author
Barnes, Betsy J
author
Eruslanov, Evgeniy
author
Fridlender, Zvi G
author
Goodridge, Helen S
author
Granot, Zvi
author
Hidalgo, Andres
author
Huttenlocher, Anna
author
Kaplan, Mariana J
author
Malanchi, Ilaria
author
Merghoub, Taha
author
Meylan, Etienne
author
Mittal, Vivek
author
Pittet, Mikael J
author
Rubio-Ponce, Andrea
author
Udalova, Irina A
author
van den Berg, Timo K
author
Wagner, Denisa D
author
Wang, Ping
author
Zychlinsky, Arturo
author
de Visser, Karin E
author
Egeblad, Mikala
author
Kubes, Paul
funder
Canadian Institutes of Health Research
funder
Terry Fox Research Institute
funder
UK Research and Innovation
funder
Medical Research Council (Reino Unido)
funder
National Institutes of Health (Estados Unidos)
funder
Israel Science Foundation
funder
Rosetrees Trust
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Wellcome Trust
funder
Swiss National Science Foundation
2023-04-27T11:45:36Z
2023-04-27T11:45:36Z
2022-06-06
J Exp Med. 2022 Jun 6;219(6):e20220011.
http://hdl.handle.net/20.500.12105/15923
35522219
10.1084/jem.20220011
1540-9538
The Journal of experimental medicine
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
eng
Neutrophil phenotypes and functions in cancer: A consensus statement.
review
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https://repisalud.isciii.es/bitstreams/84185724-7220-4fa1-ab5b-dbbb1c109ba1/download
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Neutrophil phenotypes J Exp Med 2022.pdf
URL
https://repisalud.isciii.es/bitstreams/a39747a4-8cc6-4c55-9d78-539ee2242c98/download
File
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Neutrophil phenotypes J Exp Med 2022.pdf.txt