2026-04-29T04:09:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/159162025-05-05T09:50:54Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Campuzano, Susana author Pedrero, María author Barderas Manchado, Rodrigo author Pingarrón, José M author 2022-04 Electrochemical biosensors continue to evolve at an astonishing pace, con-solidating as competitive tools for determining a wide range of targets and relentlessly strengthening their attributes in terms of sensitivity, selectivity, simplicity, response time, and antifouling ability, making them suitable for getting a foothold in real-world applications. The design and exploitation of nanostructured or multifunctional nucleic acid or peptide biomaterials are playing a determinant role in these achievements. With the aim of high-lighting the potential and opportunities of these biomaterials, this perspec-tive article critically discusses and overviews the electrochemical biosensors reported since 2019 involving nanostructured and multifunctional DNA biomaterials, multifunctional aptamers, modern peptides, and CRISPR/Cas systems. The use of these biomaterials as recognition elements, electrode modifiers (acting as linkers or creating scaffolds with antifouling properties), enzyme substrates, and labeling/carrier agents for signal amplification is discussed through rationally and strategically selected examples, concluding with a personal perspective about the challenges to be faced and future lines of action. Adv. Mater. Technol. 2022,7:2200310. 2365-709X http://hdl.handle.net/20.500.12105/15916 10.1002/admt.202200310 2365-709X Advanced Materials Technologies Antifouling Empowered electrochemical biosensors Nanostructured and/or multifunctional biomaterials Nucleic acids Peptides Empowering Electrochemical Biosensing through Nanostructured or Multifunctional Nucleic Acid or Peptide Biomaterials