2026-04-29T07:24:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159082025-04-07T18:55:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Peris-Celda, María
author
Carrión-Navarro, Josefa
author
Palacín-Aliana, Irina
author
Sánchez-Gómez, Pilar
author
Prat-Acín, Ricardo
author
García-Romero, Noemí
author
Ayuso-Sacido, Angel
funder
Instituto de Salud Carlos III
funder
Banco Santander
funder
Francisco de Vitoria University (España)
2023-04-27T09:05:50Z
2023-04-27T09:05:50Z
2022-08
Front Oncol. 2022 Aug 24;12:923681.
2234-943X
http://hdl.handle.net/20.500.12105/15908
36091108
10.3389/fonc.2022.923681
Frontiers in oncology
Gliomas are the most common brain tumors, which present poor prognosis, due, in part, to tumor cell migration and infiltration into distant brain areas. However, the underlying mechanisms causing such effects are unknown. Hedgehog (HH)-Gli axis is one of the signaling pathways involved, with a high number of molecular mediators. In this study, we investigated the association between HH-Gli intermediates and clinical parameters. We found that high levels of SuFu are associated with high dissemination patterns in patients with glioma. Therefore, we analyzed SuFu expression data in three glioma cohorts of surgical samples (N =1,759) and modified its expression in Glioblastoma Cancer Stem Cells (GB CSC) in vitro models. Our data reveal that SuFu overexpression increases cancer stemness properties together with a migratory phenotype. This work identifies SuFu as a new molecular player in glioma cell migration and a promising target to develop blocking agents to decrease GB dissemination.
eng
SuFu = suppressor of fused
Brain tumors
Glioblastoma
Glioma
Hedgehog glioma-associated oncogene 1 (GLI1)
Migration
Suppressor of fused associates with dissemination patterns in patients with glioma
research article
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URL
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SuppressorFusedAssociatesDissemination_2022.pdf
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Supplementary_SuppressorFusedAssociatesDissemination_2022.pdf
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SuppressorFusedAssociatesDissemination_2022.pdf.txt
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https://repisalud.isciii.es/bitstreams/2ca4f8d1-3895-4a15-85e8-7a4cf6222237/download
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Supplementary_SuppressorFusedAssociatesDissemination_2022.pdf.txt