2026-04-29T07:24:21Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/159082025-04-07T18:55:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Peris-Celda, María author Carrión-Navarro, Josefa author Palacín-Aliana, Irina author Sánchez-Gómez, Pilar author Prat-Acín, Ricardo author García-Romero, Noemí author Ayuso-Sacido, Angel author 2022-08 Gliomas are the most common brain tumors, which present poor prognosis, due, in part, to tumor cell migration and infiltration into distant brain areas. However, the underlying mechanisms causing such effects are unknown. Hedgehog (HH)-Gli axis is one of the signaling pathways involved, with a high number of molecular mediators. In this study, we investigated the association between HH-Gli intermediates and clinical parameters. We found that high levels of SuFu are associated with high dissemination patterns in patients with glioma. Therefore, we analyzed SuFu expression data in three glioma cohorts of surgical samples (N =1,759) and modified its expression in Glioblastoma Cancer Stem Cells (GB CSC) in vitro models. Our data reveal that SuFu overexpression increases cancer stemness properties together with a migratory phenotype. This work identifies SuFu as a new molecular player in glioma cell migration and a promising target to develop blocking agents to decrease GB dissemination. Front Oncol. 2022 Aug 24;12:923681. 2234-943X http://hdl.handle.net/20.500.12105/15908 36091108 10.3389/fonc.2022.923681 Frontiers in oncology SuFu = suppressor of fused Brain tumors Glioblastoma Glioma Hedgehog glioma-associated oncogene 1 (GLI1) Migration Suppressor of fused associates with dissemination patterns in patients with glioma