2026-07-21T14:57:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159012025-06-13T08:57:29Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_16962col_20.500.12105_19617
Repisalud
author
Antequera, Desireé
author
Carrero, Laura
author
Cunha Alves, Victoria
author
Ferrer, Isidro
author
Hernández-Gallego, Jesús
author
Municio, Cristina
author
Carro, Eva
funder
Instituto de Salud Carlos III
funder
Research Institute Hospital 12 de Octubre
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
2023-04-26T14:06:55Z
2023-04-26T14:06:55Z
2022-07-08
Biomedicines. 2022 Jul 8;10(7):1645.
10.3390/biomedicines10071645
2227-9059
Biomedicines
35884950
http://hdl.handle.net/20.500.12105/15901
Impaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer's disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-β clearance, but it is known to be abnormally expressed in AD brains. The expression of AQPs is differentially regulated during diverse brain injuries, but, whereas AQP4 expression and function have been studied in AD, less is known about AQP5. AQP5 functions include not only water transport but also cell migration mediated by cytoskeleton regulation. Moreover, AQP5 has been reported to be expressed in astrocytes, which are regulated after ischemic and traumatic injury. Additionally, AQP5 is particularly abundant in the salivary glands suggesting that it may be a crucial factor in gland dysfunction associated with AD. Herein, we aim to determine whether AQP5 expression in submandibular glands and the brain was altered in AD. First, we demonstrated impaired AQP5 expression in submandibular glands in APP/PS1 mice and AD patients. Subsequently, we observed that AQP5 expression was upregulated in APP/PS1 cerebral cortex and confirmed its expression both in astrocytes and neurons. Our findings propose AQP5 as a significant role player in AD pathology, in addition to AQP4, representing a potential target for the treatment of AD.
eng
Alzheimer’s disease
Aquaporins
Astrocytes
Neurons
Submandibular gland
Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer's Disease
research article
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DifferentiallyAquaporin5ExpressionSubmandibular_2022.pdf
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DifferentiallyAquaporin5ExpressionSubmandibular_2022.pdf.txt