2026-04-29T04:00:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158982025-04-30T06:36:37Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
de la Cueva, Macarena
author
Antequera, Desireé
author
Ordóñez-Gutiérrez, Lara
author
Wandosell, Francisco
author
Camins, Antonio
author
Carro, Eva
author
Bartolome, Fernando
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
2023-04-26T11:41:11Z
2023-04-26T11:41:11Z
2022-06-16
Sci Rep. 2022 Jun 16;12(1):10092.
http://hdl.handle.net/20.500.12105/15898
35710783
10.1038/s41598-022-13683-3
2045-2322
Scientific reports
The most accepted hypothesis in Alzheimer's disease (AD) is the amyloid cascade which establishes that Aβ accumulation may induce the disease development. This accumulation may occur years before the clinical symptoms but it has not been elucidated if this accumulation is the cause or the consequence of AD. It is however, clear that Aβ accumulation exerts toxic effects in the cerebral cells. It is important then to investigate all possible associated events that may help to design new therapeutic strategies to defeat or ameliorate the symptoms in AD. Alterations in the mitochondrial physiology have been found in AD but it is not still clear if they could be an early event in the disease progression associated to amyloidosis or other conditions. Using APP/PS1 mice, our results support published evidence and show imbalances in the mitochondrial dynamics in the cerebral cortex and hippocampus of these mice representing very early events in the disease progression. We demonstrate in cellular models that these imbalances are consequence of Aβ accumulation that ultimately induce increased mitophagy, a mechanism which selectively removes damaged mitochondria by autophagy. Along with increased mitophagy, we also found that Aβ independently increases autophagy in APP/PS1 mice. Therefore, mitochondrial dysfunction could be an early feature in AD, associated with amyloid overload.
eng
Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer's disease experimental models
research article
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Amyloid-βImpairsMitochondrialDynamics_2022.pdf
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Supplementary_Amyloid-βImpairsMitochondrialDynamics_2022.pdf
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Amyloid-βImpairsMitochondrialDynamics_2022.pdf.txt
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Supplementary_Amyloid-βImpairsMitochondrialDynamics_2022.pdf.txt