2026-05-25T12:34:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158832024-09-27T09:15:36Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
González-Amor, María
author
Dorado, Beatriz
author
Andres, Vicente
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Progeria Research Foundation
funder
Fundación La Marató TV3
funder
Sociedad Española de Cardiología
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-04-25T09:37:54Z
2023-04-25T09:37:54Z
2023
Front Cell Dev Biol. 2023 Mar 21;11:1128594
10.3389/fcell.2023.1128594
2296-634X
Frontiers in cell and developmental biology
37025175
http://hdl.handle.net/20.500.12105/15883
Population aging and age-related cardiovascular disease (CVD) are becoming increasingly prevalent worldwide, generating a huge medical and socioeconomic burden. The complex regulation of aging and CVD and the interaction between these processes are crucially dependent on cellular stress responses. Interferon-stimulated gene-15 (ISG15) encodes a ubiquitin-like protein expressed in many vertebrate cell types that can be found both free and conjugated to lysine residues of target proteins via a post-translational process termed ISGylation. Deconjugation of ISG15 (deISGylation) is catalyzed by the ubiquitin-specific peptidase 18 (USP18). The ISG15 pathway has mostly been studied in the context of viral and bacterial infections and in cancer. This minireview summarizes current knowledge on the role of ISG15 in age-related telomere shortening, genomic instability, and DNA damage accumulation, as well as in hypertension, diabetes, and obesity, major CVD risk factors prevalent in the elderly population.
eng
Emerging roles of interferon-stimulated gene-15 in age-related telomere attrition, the DNA damage response, and cardiovascular disease.
review
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URL
https://repisalud.isciii.es/bitstreams/f814174e-a1a1-4529-a8cd-bbe149e7ab17/download
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Emerging roles of interferon Front Cell Dev Biol 2023.pdf
URL
https://repisalud.isciii.es/bitstreams/0bf9df22-6540-4818-b6e4-d18bcc79ad6d/download
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Emerging roles of interferon Front Cell Dev Biol 2023.pdf.txt