2026-04-29T02:37:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158812025-06-17T08:28:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Losada-Pérez, María
author
Hernández García-Moreno, Mamen
author
García-Ricote, Irene
author
Casas-Tinto, Sergio
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
2023-04-25T05:53:59Z
2023-04-25T05:53:59Z
2022-07
PLoS Genet. 2022 Jul 25;18(7):e1010329.
http://hdl.handle.net/20.500.12105/15881
35877760
10.1371/journal.pgen.1010329
1553-7404
PLoS genetics
Glioblastoma (GB) is the most aggressive, lethal and frequent primary brain tumor. It originates from glial cells and is characterized by rapid expansion through infiltration. GB cells interact with the microenvironment and healthy surrounding tissues, mostly neurons and vessels. GB cells project tumor microtubes (TMs) contact with neurons, and exchange signaling molecules related to Wingless/WNT, JNK, Insulin or Neuroligin-3 pathways. This cell to cell communication promotes GB expansion and neurodegeneration. Moreover, healthy neurons form glutamatergic functional synapses with GB cells which facilitate GB expansion and premature death in mouse GB xerograph models. Targeting signaling and synaptic components of GB progression may become a suitable strategy against glioblastoma. In a Drosophila GB model, we have determined the post-synaptic nature of GB cells with respect to neurons, and the contribution of post-synaptic genes expressed in GB cells to tumor progression. In addition, we document the presence of intratumoral synapses between GB cells, and the functional contribution of pre-synaptic genes to GB calcium dependent activity and expansion. Finally, we explore the relevance of synaptic genes in GB cells to the lifespan reduction caused by GB advance. Our results indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality.
eng
Synaptic components are required for glioblastoma progression in Drosophila
research article
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URL
https://repisalud.isciii.es/bitstreams/dbfb452f-05fe-4354-8168-9c064186093c/download
File
MD5
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application/pdf
SynapticComponentsRequiredGlioblastoma_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/6c8536a6-79f5-46b4-b85b-6715f388d8e2/download
File
MD5
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text/plain
SynapticComponentsRequiredGlioblastoma_2022.pdf.txt