2026-06-14T05:06:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158802025-05-05T10:08:49Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Martín-Carrasco, Clara
author
Delgado-Bonet, Pablo
author
Tomeo-Martín, Beatriz Davinia
author
Pastor, Josep
author
de la Riva, Claudia
author
Palau-Concejo, Paula
author
Del Castillo, Noemí
author
Garcia-Castro, Javier
author
Perise-Barrios, Ana Judith
funder
Alfonso X el Sabio University (España)
funder
Banco Santander
funder
Fundación Universidad Alfonso X el Sabio
funder
Comunidad de Madrid (España)
2023-04-24T14:15:10Z
2023-04-24T14:15:10Z
2022-06-28
Vet Sci. 2022 Jun 28;9(7):327.
10.3390/vetsci9070327
2306-7381
Veterinary sciences
35878344
http://hdl.handle.net/20.500.12105/15880
The use of oncolytic viruses is an innovative approach to lyse tumor cells and induce antitumor immune responses. Eight dogs diagnosed with carcinoma/adenocarcinoma were intratumorally treated with ICOCAV15, an oncolytic canine adenovirus (CAV). To evaluate the treatment's safety, a blood count, biochemistry, and coagulation test were performed before treatment and during follow-up. Immune populations were analyzed by flow cytometry. Anti-adenovirus antibodies were also determined. The immune infiltration, vascularization, and viral presence in the tumor were determined by CD3, CD4, CD20, CD31 and CAV by immunohistochemistry. All the dogs maintained a good quality of life during follow-up, and some had increased median survival time when compared with dogs treated with chemotherapy. No treatment-related adverse effects were detected. The Response Evaluation Criteria In Solid Tumors criteria were also assessed: two patients showed a partial response and the rest showed stable disease at various times during the study. ICOCAV15 was detected inside the tumor during follow-up, and antiviral antibodies were detected in all patients. Furthermore, the tumor-infiltrating immune cells increased after viral administration. Therefore, we suggest that intratumorally administered ICOCAV15 could represent as a new tool for the treatment of canine carcinoma because it is safe, well-tolerated by dogs, and shows promising results.
eng
Oncolytic Viruses
Virotherapy
Immunotherapy
ICOCAV15
Canine carcinoma
Safety and Efficacy of an Oncolytic Adenovirus as an Immunotherapy for Canine Cancer Patients
research article
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SafetyEfficacyOncolyticAdenovirus_2022.pdf.txt
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