2026-07-22T02:10:50Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/158712025-05-14T10:46:33Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud author Lange, Rosa author Vogel, Nina author Schmidt, Phillipp author Gerofke, Antje author Luijten, Mirjam author Bil, Wieneke author Santonen, Tiina author Schoeters, Greet author Gilles, Liese author Sakhi, Amrit K author Haug, Line S author Jensen, Tina K author Frederiksen, Hanne author Koch, Holger M author Szigeti, Tamás author Szabados, Máté author Tratnik, Janja Snoj author Mazej, Darja author Gabriel, Catherine author Sarigiannis, Dimosthenis author Dzhedzheia, Vazha author Karakitsios, Spyros author Rambaud, Loïc author Riou, Margaux author Koppen, Gudrun author Covaci, Adrian author Zvonař, Martin author Piler, Pavel author Klánová, Jana author Fábelová, Lucia author Richterová, Denisa author Kosjek, Tina author Runkel, Agneta author Pedraza-Diaz, Susana author Verheyen, Veerle author Bastiaensen, Michiel author Esteban-Lopez, Marta author Castaño, Argelia author Kolossa-Gehring, Marike funder Unión Europea. Comisión Europea. H2020 funder Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Alemania) funder The Research Council of Norway funder Ministerio de Agricultura, Pesca y Alimentación (España) funder Instituto de Salud Carlos III funder Santé Publique France funder Ministère de la Santé (Francia) funder Novo Nordisk Foundation funder Norwegian Institute of Public Health funder Jožef Stefan Institute funder National Public Health Center (Hungría) funder Ministry of Health (Eslovaquia) funder Slovak Research and Development Agency funder Government of Flanders funder Odense University Hospital (Dinamarca) funder Region of Southern Denmark funder University of Southern Denmark (Dinamarca) funder Centre on Endocrine Disruptors (Dinamarca) funder Danish Research Council funder MEYS 2023-04-21T11:17:26Z 2023-04-21T11:17:26Z 2022-09 Int J Hyg Environ Health. 2022 Sep;246:114052. 10.1016/j.ijheh.2022.114052 1618-131X International journal of hygiene and environmental health 36323174 http://hdl.handle.net/20.500.12105/15871 The European Human Biomonitoring Initiative (HBM4EU) assessed human biomonitoring data on phthalates in children and adolescents, that were sampled between 2014 and 2021, in a harmonised way. These so-called “HBM4EU Aligned Studies” revealed that almost all children and adolescents were exposed to multiple phthalates concurrently. Some phthalates have been shown to act in a dose-additive manner, thus, a mixture risk assessment is warranted. In our study, we determine the risk from combined exposure to five anti-androgenic phthalates, namely DEHP, DiBP, DnBP, BBzP and DiNP by making use of the hazard index (HI) approach. Toxicologically-based human biomonitoring guidance values (HBM-GVs) derived within the framework of HBM4EU served as basis. Our results show that exposures of 17% of children and adolescents from twelve European countries resulted in hazard indices (HI) > 1 with an HI of 1.77 at the 95th percentile (geometric mean, GM = 0.44). Main drivers for the mixture risk are DnBP and DiBP. Generalized Linear Model (GLM) analysis including four major exposure determinants (age, sex, European region, sampling year) simultaneously reveal differences for the European regions and between sampling years. Children and adolescents living in the Eastern region of Europe have on average, higher HIs (GM=0.58) than in the Southern region (GM = 0.36) and Western region (GM = 0.42). Moreover, participants from which urine samples were taken in the earlier years (2014–2016) seem to have higher average HI levels than participants from studies with later sampling periods. Strikingly, the majority (63%) of participants with HIs > 1 would have gone unnoticed in single substance risk assessments as individual phthalates levels were below corresponding HBM-GVs. Thus, our results underline the importance of mixture risk assessment approaches to adequately address risks from concurrent chemical exposure. eng Cumulative risk assessment HBM4EU Human biomonitoring Mixtures Phthalates Cumulative risk assessment of five phthalates in European children and adolescents research article 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 URL https://repisalud.isciii.es/bitstreams/20fdc0fb-b09a-4cbf-97fa-3e4ccff748fe/download File MD5 495bb538c2852ba6780c9b1615eecdd0 2458885 application/pdf CumulativeRiskAssessmentFive_2022.pdf URL https://repisalud.isciii.es/bitstreams/c1350e42-9541-498d-bf80-ca84b562cb9f/download File MD5 a64e2dc2d687410a3e69bbe079a87d1f 720869 application/pdf Supplementary_CumulativeRiskAssessmentFive_2022.pdf URL https://repisalud.isciii.es/bitstreams/8ed13bd1-ee07-4033-bda0-ca71a53c5601/download File MD5 97f80e4c0a5d26a6150542b14bc1376f 99173 text/plain CumulativeRiskAssessmentFive_2022.pdf.txt URL https://repisalud.isciii.es/bitstreams/da5584fb-142b-485b-a54e-d3e920cc3659/download File MD5 1f9f8b31cadc4be45d9b1a414c7a6c9a 8565 text/plain Supplementary_CumulativeRiskAssessmentFive_2022.pdf.txt