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oai:repisalud.isciii.es:20.500.12105/158652025-06-09T09:07:45Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16983col_20.500.12105_16990

00925njm 22002777a 4500 dc García-Pérez, Javier author Lope Carvajal, Virginia author Fernandez de Larrea-Baz, Nerea author Molina, Antonio J author Tardón, Adonina author Alguacil, Juan author Perez-Gomez, Beatriz author Moreno, Victor author Guevara, Marcela author Castaño-Vinyals, Gemma author Jimenez-Moleon, Jose J. author Gómez-Acebo, Inés author Molina-Barceló, Ana author Martín, Vicente author Kogevinas, Manolis author Pollan-Santamaria, Marina author Aragones, Nuria author 2021-06-01 Background: Gastric cancer is the fifth most frequent tumor worldwide. In Spain, it presents a large geographic variability in incidence, suggesting a possible role of environmental factors in its etiology. Therefore, epidemiologic research focused on environmental exposures is necessary. Objectives: To assess the association between risk of gastric cancer (by histological type and tumor site) and residential proximity to industrial installations, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer conducted in Spain (MCC-Spain). Methods: In this study, 2664 controls and 137 gastric cancer cases from 9 provinces, frequency matched by province of residence, age, and sex were included. Distances from the individuals' residences to the 106 industries located in the study areas were computed. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industries, adjusting for matching variables and potential confounders. Results: Overall, no excess risk of gastric cancer was observed in people living close to the industrial installations, with ORs ranging from 0.73 (at ≤2.5 km) to 0.93 (at ≤1.5 km). However, by industrial sector, excess risks (OR; 95%CI) were found near organic chemical industry (3.51; 1.42-8.69 at ≤2 km), inorganic chemical industry (3.33; 1.12-9.85 at ≤2 km), food/beverage sector (2.48; 1.12-5.50 at ≤2 km), and surface treatment using organic solvents (3.59; 1.40-9.22 at ≤3 km). By specific pollutant, a statistically significant excess risk (OR; 95%CI) was found near (≤3 km) industries releasing nonylphenol (6.43; 2.30-17.97) and antimony (4.82; 1.94-12.01). Conclusions: The results suggest no association between risk of gastric cancer and living in the proximity to the industrial facilities as a whole. However, a few associations were detected near some industrial sectors and installations releasing specific pollutants. Environ Pollut. 2021 Jun 1;278:116854. 10.1016/j.envpol.2021.116854 1873-6424 0269-7491 Environmental pollution (Barking, Essex : 1987) 33714062 http://hdl.handle.net/20.500.12105/15865 Case-control study Gastric cancer Industrial pollution MCC-Spain Residential proximity Risk factor Risk of gastric cancer in the environs of industrial facilities in the MCC-Spain study