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oai:repisalud.isciii.es:20.500.12105/158622025-04-04T16:50:26Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19610col_20.500.12105_16959

00925njm 22002777a 4500 dc Rosolen, Valentina author Giordani, Elisa author Mariuz, Marika author Parpinel, Maria author Ronfani, Luca author Vecchi Brumatti, Liza author Bin, Maura author Calamandrei, Gemma author Mustieles, Vicente author Gilles, Liese author Govarts, Eva author Baken, Kirsten author Rodriguez Martin, Laura author Schoeters, Greet author Sepai, Ovnair author Sovcikova, Eva author Fábelová, Lucia author Šidlovská, Miroslava author Kolena, Branislav author Kold Jensen, Tina author Frederiksen, Hanne author Kolossa-Gehring, Marike author Lange, Rosa author Apel, Petra author Castaño, Argelia author Esteban-Lopez, Marta author Jacobs, Griet author Voorspoels, Stefan author Jurdáková, Helena author Górová, Renáta author Barbone, Fabio author 2022-09-16 Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL® DINCH) on children's neurodevelopment is limited. The aim of the present research is to evaluate the association between phthalate/HEXAMOLL® DINCH exposure and child neurodevelopment in three European cohorts involved in HBM4EU Aligned Studies. Participating subjects were school-aged children belonging to the Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, and PCB cohort, Slovakia. In each cohort, children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score (FSIQ) of the Wechsler Intelligence Scale of Children test using three different editions. The children's urine samples, collected for one point in time concurrently with the neurodevelopmental evaluation, were analyzed for several phthalates/HEXAMOLL® DINCH biomarkers. The relation between phthalates/HEXAMOLL® DINCH and FSIQ was explored by applying separate multiple linear regressions in each cohort. The means and standard deviations of FSIQ were 109 ± 11 (NAC-II), 98 ± 12 (OCC), and 81 ± 15 (PCB cohort). In NAC-II, direct associations between FSIQ and DEHP's biomarkers were found: 5OH-MEHP+5oxo-MEHP (β = 2.56; 95% CI 0.58-4.55; N = 270), 5OH-MEHP+5cx-MEPP (β = 2.48; 95% CI 0.47-4.49; N = 270) and 5OH-MEHP (β = 2.58; 95% CI 0.65-4.51; N = 270). On the contrary, in the OCC the relation between DEHP's biomarkers and FSIQ tended to be inverse but imprecise (p-value ≥ 0.10). No associations were found in the PCB cohort. FSIQ was not associated with HEXAMOLL® DINCH in any cohort. In conclusion, these results do not provide evidence of an association between concurrent phthalate/DINCHHEXAMOLLR DINCH exposure and IQ in children. Toxics. 2022 Sep 16;10(9):538. 10.3390/toxics10090538 2305-6304 Toxics 36136503 http://hdl.handle.net/20.500.12105/15862 Full-Scale Intelligence Quotient HBM4EU HEXAMOLL® DINCH WISC Aligned studies Children Environmental contaminants Human biomonitoring Neurodevelopment Phthalates Concurrent Assessment of Phthalates/HEXAMOLL® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies