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00925njm 22002777a 4500 dc González-Herrera, Antonio author Rodriguez-Blazquez, Carmen author Romay-Barja, Maria author Falcón-Romero, María author Ayala, Alba author Forjaz, Maria João author 2022-12-02 This study aims at describing the evolution of Spanish population preventive practices during the COVID-19 pandemic of the between January and June 2021, and differences by age group. Data was drawn from the COSMO-Spain online survey, rounds (R) 4, 5 and 6. Multiple linear regression models with preventive practices as dependent variable were performed. Preventive practices (p = 0.001) and concern about coronavirus (p = 0.003) decreased throughout the three rounds, knowledge decreased from R4 to R6 (p = 0.002) and health literacy had a higher value in R6 (p < 0.001). Older the age was associated with higher the frequency of preventive practices, and levels of health literacy and concern about coronavirus (p < 0.001). The regression model showed that, in the 18-29 year group, a greater frequency of preventive practices was associated with being female (β = 0.20; p < 0.001), greater concern about coronavirus (β = 0.16; p < 0.018) and frequency of information seeking (β = 0.24; p < 0.001). For 61 years old and older, a higher frequency of preventive practices was associated with greater concern about coronavirus (β = 0.21; p < 0.002) and lower pandemic fatigue (β = - 0.13; p < 0.037). These findings point to the need for effective public health interventions tailored to the characteristics of age population groups. Sci Rep. 2022 Dec 2;12(1):20863. 10.1038/s41598-022-25353-5 2045-2322 Scientific reports 36460702 http://hdl.handle.net/20.500.12105/15858 Age differences in knowledge, attitudes and preventive practices during the COVID-19 pandemic in Spain