2026-04-27T03:42:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158522025-06-24T17:24:58Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609
Repisalud
author
Peñuelas, Marina
author
Guerrero-Vadillo, María
author
Valdezate, Sylvia
author
Zamora, María Jesús
author
Leon-Gomez, Inmaculada
author
Flores-Cuéllar, Ángeles
author
Carrasco, Gema
author
Diaz Garcia, Maria Oliva
author
Varela Martinez, Maria del Carmen
2023-04-19T10:09:05Z
2023-04-19T10:09:05Z
2023
Toxins (Basel). 2023;15(1):2.
http://hdl.handle.net/20.500.12105/15852
36668823
10.3390/toxins15010002
2072-6651
Toxins
Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum. There are different routes of acquisition, food-borne and infant/intestinal being the most frequent presentation, and antitoxin is the treatment of choice in all cases. In Spain, botulism is under surveillance, and case reporting is mandatory. Methods: This retrospective study attempts to provide a more complete picture of the epidemiology of botulism in Spain from 1997 to 2019 and an assessment of the treatment, including the relationship between a delay in antitoxin administration and the length of hospitalization using the Cox proportional hazards test and Kruskal-Wallis test, and an approach to the frequency of adverse events, issues for which no previous national data have been published. Results: Eight of the 44 outbreaks were associated with contaminated commercial foods involving ≤7 cases/outbreak; preserved vegetables were the main source of infection, followed by fish products; early antitoxin administration significantly reduces the hospital stay, and adverse reactions to the antitoxin affect around 3% of treated cases.
eng
Botulism
Food-borne botulism
Infant botulism
Botulinum neurotoxins
Botulism antitoxin
Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997-2019
research article
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URL
https://repisalud.isciii.es/bitstreams/cd3821fe-6a0e-4b57-9d5e-bf46f0c9f589/download
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BotulismSpainEpidemiologyOutcomes_2022.pdf
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Supplementary_BotulismSpainEpidemiologyOutcomes_2022.pdf
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BotulismSpainEpidemiologyOutcomes_2022.pdf.txt
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Supplementary_BotulismSpainEpidemiologyOutcomes_2022.pdf.txt