2026-04-27T03:42:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/158522025-06-24T17:24:58Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609

00925njm 22002777a 4500 dc Peñuelas, Marina author Guerrero-Vadillo, María author Valdezate, Sylvia author Zamora, María Jesús author Leon-Gomez, Inmaculada author Flores-Cuéllar, Ángeles author Carrasco, Gema author Diaz Garcia, Maria Oliva author Varela Martinez, Maria del Carmen author 2023 Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum. There are different routes of acquisition, food-borne and infant/intestinal being the most frequent presentation, and antitoxin is the treatment of choice in all cases. In Spain, botulism is under surveillance, and case reporting is mandatory. Methods: This retrospective study attempts to provide a more complete picture of the epidemiology of botulism in Spain from 1997 to 2019 and an assessment of the treatment, including the relationship between a delay in antitoxin administration and the length of hospitalization using the Cox proportional hazards test and Kruskal-Wallis test, and an approach to the frequency of adverse events, issues for which no previous national data have been published. Results: Eight of the 44 outbreaks were associated with contaminated commercial foods involving ≤7 cases/outbreak; preserved vegetables were the main source of infection, followed by fish products; early antitoxin administration significantly reduces the hospital stay, and adverse reactions to the antitoxin affect around 3% of treated cases. Toxins (Basel). 2023;15(1):2. http://hdl.handle.net/20.500.12105/15852 36668823 10.3390/toxins15010002 2072-6651 Toxins Botulism Food-borne botulism Infant botulism Botulinum neurotoxins Botulism antitoxin Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997-2019