2026-04-29T07:24:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158382024-09-27T08:48:58Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rodríguez-Fernández, Blanca
author
Vilor-Tejedor, Natalia
author
Arenaza-Urquijo, Eider M
author
Sánchez-Benavides, Gonzalo
author
Suárez-Calvet, Marc
author
Operto, Grégory
author
Minguillón, Carolina
author
Fauria, Karine
author
Kollmorgen, Gwendlyn
author
Suridjan, Ivonne
author
de Moura, Manuel Castro
author
Piñeyro, David
author
Esteller, Manel
author
Blennow, Kaj
author
Zetterberg, Henrik
author
De Vivo, Immaculata
author
Molinuevo, José Luis
author
Navarro, Arcadi
author
Gispert, Juan Domingo
author
Sala-Vila, Aleix
author
Crous-Bou, Marta
funder
Alzheimers Association
funder
Fundación La Caixa
funder
Government of Catalonia (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Comisión Europea. H2020
funder
Instituto de Salud Carlos III
funder
Marie Curie
funder
Swedish Research Council
2023-04-18T13:15:06Z
2023-04-18T13:15:06Z
2022-11-07
Alzheimers Res Ther. 2022 Nov 7;14(1):167
http://hdl.handle.net/20.500.12105/15838
36345036
10.1186/s13195-022-01101-9
1758-9193
Alzheimer's research & therapy
Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related signatures, N = 1134; and cerebrospinal fluid biomarkers (CSF) of AD and neurodegeneration, N = 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted in the context of the ALFA (ALzheimer and FAmilies) study, a population of cognitively healthy individuals at risk of AD. A total of 20 single nucleotide polymorphisms associated with TL were used to determine the effect of TL on AD endophenotypes. Analyses were adjusted by age, sex, and years of education. Stratified analyses by APOE-ɛ4 status and polygenic risk score of AD were conducted. MR analysis revealed significant associations between genetically predicted longer TL and lower levels of CSF Aβ and higher levels of CSF NfL only in APOE-ɛ4 non-carriers. Moreover, inheriting longer TL was associated with greater cortical thickness in age and AD-related brain signatures and lower levels of CSF p-tau among individuals at a high genetic predisposition to AD. Further observational analyses are warranted to better understand these associations.
eng
Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study.
journal article
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Genetically predicted telomere Alzheimers Res Ther 2022.pdf
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Genetically predicted telomere Alzheimers Res Ther 2022.pdf.txt