2026-05-21T23:07:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/158222025-04-30T06:45:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Singh, David E
author
Olmedo-Lucerón, Carmen
author
Limia Sánchez, Aurora
author
Guzman Merino, Miguel
author
Duran Gonzalez, Christian
author
Delgado-Sanz, Concepcion
author
Gomez-Barroso, Diana
author
Carretero, Jesus
author
Marinescu, Maria-Cristina
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Carlos III University of Madrid (España)
2023-04-17T09:44:05Z
2023-04-17T09:44:05Z
2022-12-09
BMJ Open. 2022 Dec 9;12(12):e065937.
10.1136/bmjopen-2022-065937
2044-6055
BMJ open
36600331
http://hdl.handle.net/20.500.12105/15822
Objective: We analyse the impact of different vaccination strategies on the propagation of COVID-19 within the Madrid metropolitan area, starting on 27 December 2020 and ending in Summer of 2021. Materials and methods: The predictions are based on simulation using EpiGraph, an agent-based COVID-19 simulator. We first summarise the different models implemented in the simulator, then provide a comprehensive description of the vaccination model and define different vaccination strategies. The simulator-including the vaccination model-is validated by comparing its results with real data from the metropolitan area of Madrid during the third COVID-19 wave. This work considers different COVID-19 propagation scenarios for a simulated population of about 5 million. Results: The main result shows that the best strategy is to vaccinate first the elderly with the two doses spaced 56 days apart; this approach reduces the final infection rate by an additional 6% and the number of deaths by an additional 3% with respect to vaccinating first the elderly at the interval recommended by the vaccine producer. The reason is the increase in the number of vaccinated individuals at any time during the simulation. Conclusion: The existing level of detail and maturity of EpiGraph allowed us to evaluate complex scenarios and thus use it successfully to help guide the strategy for the COVID-19 vaccination campaign of the Spanish health authorities.
eng
COVID-19
Epidemiology
Health policy
Public health
Health Services Administration & Management
Evaluation of vaccination strategies for the metropolitan area of Madrid via agent-based simulation
research article
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EvaluationVaccinationStrategiesMetropolitan_2022.pdf
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EvaluationVaccinationStrategiesMetropolitan_2022.pdf.txt