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oai:repisalud.isciii.es:20.500.12105/157982025-05-08T18:44:23Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud author Ward, Sarah V author Burton, Anya author Tamimi, Rulla M author Pereira, Ana author Garmendia, Maria Luisa author Pollan-Santamaria, Marina author Boyd, Norman F author Dos-Santos-Silva, Isabel author Maskarinec, Gertraud author Perez-Gomez, Beatriz author Vachon, Celine author Miao, Hui author Lajous, Martín author López-Ridaura, Ruy author Bertrand, Kimberly author Kwong, Ava author Ursin, Giske author Lee, Eunjung author Ma, Huiyan author Vinnicombe, Sarah author Moss, Sue author Allen, Steve author Ndumia, Rose author Vinayak, Sudhir author Teo, Soo-Hwang author Mariapun, Shivaani author Peplonska, Beata author Bukowska-Damska, Agnieszka author Nagata, Chisato author Hopper, John author Giles, Graham author Ozmen, Vahit author Aribal, Mustafa Erkin author Schüz, Joachim author van Gils, Carla H author Wanders, Johanna O P author Sirous, Reza author Sirous, Mehri author Hipwell, John author Kim, Jisun author Lee, Jong Won author Dickens, Caroline author Hartman, Mikael author Chia, Kee-Seng author Scott, Christopher author Chiarelli, Anna M author Linton, Linda author Flugelman, Anath Arzee author Salem, Dorria author Kamal, Rasha author McCormack, Valerie author Stone, Jennifer funder NIH - National Cancer Institute (NCI) (Estados Unidos) funder International Agency for Research on Cancer funder Cancer Council Western Australia (Australia) funder Cancer Council Victoria (Australia) funder National Health and Medical Research Council (Australia) funder National Breast Cancer Foundation (Australia) funder Fondo Nacional de Desarrollo Científico y Tecnológico (Chile) funder World Cancer Research Fund International funder Isfahan University of Technology (Irán) funder Consejo Nacional de Ciencia y Tecnología (México) funder Unión Europea. Comisión Europea funder Dutch Cancer Society (Holanda) funder Netherlands Organisation for Health Research and Development funder National Medical Research Council (Singapur) funder National University Cancer Institute (Singapur) funder Instituto de Salud Carlos III funder Engineering and Physical Sciences Research Council (Reino Unido) funder Cancer Research UK (Reino Unido) funder University of Western Australia (Australia) funder Australia VicHealth funder National Cancer Institute (Canada) funder World Cancer Research Fund International funder Larry Ellison Foundation funder Isfahan University of Technology (Irán) funder Israel Cancer Association funder Asan Medical Center (Korea) funder Malaysia Sime Darby LPGA Tournament funder Ministry of Education University (Malasia) funder University of Malaya (Malasia) funder American Institute for Cancer Research funder Ministry of Health (Holanda) funder South Africa Pink Drive funder Federación Española de Padres de Niños con Cáncer funder Turkey-Roche Mustahzarlari San funder Breast Cancer Campaign (Reino Unido) funder Da Costa Foundation funder Susan G. Komen Breast Cancer Foundation 2023-04-13T11:19:53Z 2023-04-13T11:19:53Z 2022-07-14 Breast Cancer Res. 2022 Jul 14;24(1):49. 10.1186/s13058-022-01545-9 1465-542X Breast cancer research : BCR 35836268 http://hdl.handle.net/20.500.12105/15798 Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk. Methods: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. Results: In pooled analyses, later age at menarche was associated with higher per cent density (β√PD = 0.023 SE = 0.008, P = 0.003) and larger dense area (β√DA = 0.032 SE = 0.010, P = 0.002). Taller women had larger dense area (β√DA = 0.069 SE = 0.028, P = 0.012) and higher per cent density (β√PD = 0.044, SE = 0.023, P = 0.054), although the observed effect on per cent density depended upon the adjustment used for body size. Similar overall effect estimates were observed in meta-analyses across population groups. Conclusions: In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density. eng Mammographic density Menarche Height Breast cancer The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density research article 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 URL https://repisalud.isciii.es/bitstreams/f7d7e947-999b-4d1d-bcb8-92e432dd1c45/download File MD5 3c2e147827d339a0f828d9aef0c2b25b 3637487 application/pdf AssociationAgeMenarcheAdult_2022.pdf URL https://repisalud.isciii.es/bitstreams/eaaa900a-b776-43e1-9586-4ccd8d3299ca/download File MD5 bb44dc3b939664dcd9e809875c4e9c3d 62224 text/plain AssociationAgeMenarcheAdult_2022.pdf.txt