2026-04-29T12:23:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157882025-05-08T07:49:10Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974
Repisalud
author
Orive, Miren
author
Anton-Ladislao, Ane
author
Lázaro, Santiago
author
González, Nerea
author
Baré, Marisa
author
Fernandez de Larrea-Baz, Nerea
author
Redondo, Maximino
author
Bilbao, Amaia
author
Sarasqueta, Cristina
author
Aguirre, Urko
author
Quintana, Jose Maria
author
REDISSEC-CARESS/CCR group
funder
Consejo Superior de Investigaciones Científicas (España)
funder
Conferencia de Rectores de las Universidades Españolas
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Basque Government (España)
funder
RETICS-Servicios de Salud Orientados a Enfermedades Crónicas (REDISSEC-ISCIII) (España)
2023-04-12T13:32:16Z
2023-04-12T13:32:16Z
2022-10
Support Care Cancer. 2022 Oct;30(10):7943-7954.
10.1007/s00520-022-07177-1
1433-7339
0941-4355
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
35737143
http://hdl.handle.net/20.500.12105/15788
Purpose: Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods: Prospective observational cohort study including colorectal cancer (CRC) patients having undergone surgery in nineteen public hospitals who were monitored from their diagnosis, intervention and at 1-, 2-, 3-, and 5-year periods thereafter by gathering HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariable generalized linear mixed models were used. Results: Predictors of Euroqol-5D-5L (EQ-5D-5L) changes were having worse baseline HRQoL; being female; higher Charlson index score (more comorbidities); complications during admission and 1 month after surgery; having a stoma after surgery; and needing or being in receipt of social support at baseline. For EORTC-QLQ-C30, predictors of changes were worse baseline EORTC-QLQ-C30 score; being female; higher Charlson score; complications during admission and 1 month after admission; receiving adjuvant chemotherapy; and having a family history of CRC. Predictors of changes in HADS anxiety were being female and having received adjuvant chemotherapy. Greater depression was associated with greater baseline depression; being female; higher Charlson score; having complications 1 month after intervention; and having a stoma. A deterioration in all HRQoL questionnaires in the previous year was related to death in the following year. Conclusions: These findings should enable preventive follow-up programs to be established for such patients in order to reduce their psychological distress and improve their HRQoL to as great an extent as possible.
eng
Colorectal cancer
Patient-reported outcome measures
Health-related quality of life
Cohort studies
Longitudinal studies
Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up
research article
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URL
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AnxietyDepressionHealth-relatedQualityLife_2022.pdf
URL
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AnxietyDepressionHealth-relatedQualityLife_2022.pdf.txt