2026-05-21T23:52:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157862024-05-27T19:32:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Gallinat, Alex
author
Mendieta, Guiomar
author
Vilahur, Gemma
author
Padró, Teresa
author
Badimon, Lina
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Instituto de Salud Carlos III
2023-04-12T11:02:27Z
2023-04-12T11:02:27Z
2022
Front Pharmacol. 2022 Sep 23;13:1002755.
10.3389/fphar.2022.1002755
1663-9812
Frontiers in pharmacology
36210822
http://hdl.handle.net/20.500.12105/15786
Cardiovascular diseases, and particularly acute myocardial infarction (MI), are the most common causes of death worldwide. Infarct size is the major predictor of clinical outcomes in MI. The Parkinson's disease associated protein, DJ-1 (also known as PARK7), is a multifunctional protein with chaperone, redox sensing and mitochondrial homeostasis activities. Previously, we provided the evidence for a central role of endogenous DJ-1 in the cardioprotection of post-conditioning. In the present study, we tested the hypothesis that systemic administration of recombinant DJ-1 exerts cardioprotective effects in a mouse model of MI and also explored the associated transcriptional response. We report a significant treatment-induced reduction in infarct size, leukocyte infiltration, apoptosis and oxidative stress. Effects potentially mediated by G-protein-coupled receptor signaling and modulation of the immune response. Collectively, our results indicate a protective role for the exogenously administrated DJ-1 upon MI, and provide the first line of evidence for an extracellular activity of DJ-1 regulating cardiac injury in vivo.
eng
DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction.
journal article
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DJ_1 administration exerts cardioprotection Front Pharmacol 2022.pdf
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DJ_1 administration exerts cardioprotection Front Pharmacol 2022.pdf.txt