2026-06-14T03:52:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157822024-09-27T09:13:18Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Steg, Philippe Gabriel
author
Bhatt, Deepak L
author
James, Stefan K
author
Darlington, Oliver
author
Hoskin, Louise
author
Simon, Tabassome
author
Fox, Kim M
author
Leiter, Lawrence A
author
Mehta, Shamir R
author
Harrington, Robert A
author
Himmelmann, Anders
author
Ridderstråle, Wilhelm
author
Andersson, Marielle
author
Bueno, Hector
author
De Luca, Leonardo
author
Tank, Amarjeet
author
Mellström, Carl
author
McEwan, Phil
funder
AstraZeneca
2023-04-12T09:54:10Z
2023-04-12T09:54:10Z
2022-12-02
Eur Heart J Cardiovasc Pharmacother. 2022 Dec 2;8(8):777-785.
10.1093/ehjcvp/pvac032
2055-6845
European heart journal. Cardiovascular pharmacotherapy
35488865
http://hdl.handle.net/20.500.12105/15782
To conduct a health economic evaluation of ticagrelor in patients with type 2 diabetes and coronary artery disease (CAD) from a multinational payer perspective. Cost-effectiveness and cost-utility of ticagrelor were evaluated in the overall effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study (THEMIS) trial population and in the predefined patient group with prior percutaneous coronary intervention.
A Markov model was developed to extrapolate patient outcomes over a lifetime horizon. The primary outcome was incremental cost-effectiveness ratios (ICERs), which were compared with conventional willingness-to-pay thresholds [€47 000/quality-adjusted life-year (QALY) in Sweden and €30 000/QALY in other countries].Treatment with ticagrelor resulted in QALY gains of up to 0.045 in the overall population and 0.099 in patients with percutaneous coronary intervention (PCI). Increased costs and benefits translated to ICERs ranged between €27 894 and €42 252/QALY across Sweden, Germany, Italy, and Spain in the overall population. In patients with prior PCI, estimated ICERs improved to €18 449, €20 632, €20 233, and €13 228/QALY in Sweden, Germany, Italy, and Spain, respectively, driven by higher event rates and treatment benefit.
Based on THEMIS results, ticagrelor plus aspirin compared with aspirin alone may be cost-effective in some European countries in patients with T2DM and CAD and no prior myocardial infarction (MI) or stroke. Additionally, ticagrelor is likely to be cost-effective across European countries in patients with a history of PCI.
eng
Cost-effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease: a European economic evaluation of the THEMIS trial.
journal article
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Cost_effectiveness of ticagrelor Eur Heart J Cardiovasc Pharmacother 2022.pdf
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Cost_effectiveness of ticagrelor Eur Heart J Cardiovasc Pharmacother 2022.pdf.txt