2026-06-14T02:27:59Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157822024-09-27T09:13:18Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Steg, Philippe Gabriel author Bhatt, Deepak L author James, Stefan K author Darlington, Oliver author Hoskin, Louise author Simon, Tabassome author Fox, Kim M author Leiter, Lawrence A author Mehta, Shamir R author Harrington, Robert A author Himmelmann, Anders author Ridderstråle, Wilhelm author Andersson, Marielle author Bueno, Hector author De Luca, Leonardo author Tank, Amarjeet author Mellström, Carl author McEwan, Phil author 2022-12-02 To conduct a health economic evaluation of ticagrelor in patients with type 2 diabetes and coronary artery disease (CAD) from a multinational payer perspective. Cost-effectiveness and cost-utility of ticagrelor were evaluated in the overall effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study (THEMIS) trial population and in the predefined patient group with prior percutaneous coronary intervention. A Markov model was developed to extrapolate patient outcomes over a lifetime horizon. The primary outcome was incremental cost-effectiveness ratios (ICERs), which were compared with conventional willingness-to-pay thresholds [€47 000/quality-adjusted life-year (QALY) in Sweden and €30 000/QALY in other countries].Treatment with ticagrelor resulted in QALY gains of up to 0.045 in the overall population and 0.099 in patients with percutaneous coronary intervention (PCI). Increased costs and benefits translated to ICERs ranged between €27 894 and €42 252/QALY across Sweden, Germany, Italy, and Spain in the overall population. In patients with prior PCI, estimated ICERs improved to €18 449, €20 632, €20 233, and €13 228/QALY in Sweden, Germany, Italy, and Spain, respectively, driven by higher event rates and treatment benefit. Based on THEMIS results, ticagrelor plus aspirin compared with aspirin alone may be cost-effective in some European countries in patients with T2DM and CAD and no prior myocardial infarction (MI) or stroke. Additionally, ticagrelor is likely to be cost-effective across European countries in patients with a history of PCI. Eur Heart J Cardiovasc Pharmacother. 2022 Dec 2;8(8):777-785. 10.1093/ehjcvp/pvac032 2055-6845 European heart journal. Cardiovascular pharmacotherapy 35488865 http://hdl.handle.net/20.500.12105/15782 Cost-effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease: a European economic evaluation of the THEMIS trial.