2026-04-29T16:56:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157732025-03-20T10:52:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Alarcón-Gil, Jesús
author
Sierra-Magro, Ana
author
Morales-Garcia, Jose A
author
Sanz-SanCristobal, Marina
author
Alonso-Gil, Sandra
author
Cortes-Canteli, Marta
author
Niso-Santano, Mireia
author
Martínez-Chacón, Guadalupe
author
Fuentes, Jose M
author
Santos, Angel
author
Perez-Castillo, Ana
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2023-04-12T08:47:44Z
2023-04-12T08:47:44Z
2022-07-26
Cells. 2022 Jul 26;11(15):2297
10.3390/cells11152297
2073-4409
Cells
35892594
http://hdl.handle.net/20.500.12105/15773
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer's disease. The principal pathological feature of PD is the progressive loss of dopaminergic neurons in the ventral midbrain. This pathology involves several cellular alterations: oxidative stress, mitochondrial dysfunction, loss of proteostasis, and autophagy impairment. Moreover, in recent years, lipid metabolism alterations have become relevant in PD pathogeny. The modification of lipid metabolism has become a possible way to treat the disease. Because of this, we analyzed the effect and possible mechanism of action of linoleic acid (LA) on an SH-SY5Y PD cell line model and a PD mouse model, both induced by 6-hydroxydopamine (6-OHDA) treatment. The results show that LA acts as a potent neuroprotective and anti-inflammatory agent in these PD models. We also observed that LA stimulates the biogenesis of lipid droplets and improves the autophagy/lipophagy flux, which resulted in an antioxidant effect in the in vitro PD model. In summary, we confirmed the neuroprotective effect of LA in vitro and in vivo against PD. We also obtained some clues about the novel neuroprotective mechanism of LA against PD through the regulation of lipid droplet dynamics.
eng
Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy.
journal article
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URL
https://repisalud.isciii.es/bitstreams/af534ce7-3261-464c-acd4-2132c28bbdbf/download
File
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Neuroprotective and Anti_Inflammatory Cells 2022.pdf
URL
https://repisalud.isciii.es/bitstreams/a559d2a7-34c7-434d-a83c-e1355763172c/download
File
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Neuroprotective and Anti_Inflammatory Cells 2022.pdf.txt