2026-05-14T08:20:37Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157532024-09-27T09:57:51Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Val-Blasco, Almudena
author
Prieto, Patricia
author
Jaén, Rafael Iñigo
author
Gil-Fernández, Marta
author
Pajares, Marta
author
Domenech, Nieves
author
Terrón, Verónica
author
Tamayo, María
author
Jorge, Inmaculada
author
Vazquez, Jesus
author
Bueno-Sen, Andrea
author
Vallejo-Cremades, María Teresa
author
Pombo-Otero, Jorge
author
Sanchez-García, Sergio
author
Ruiz-Hurtado, Gema
author
Gómez, Ana María
author
Zaragoza, Carlos
author
Crespo-Leiro, María Generosa
author
López-Collazo, Eduardo
author
Cuadrado, Antonio
author
Delgado, Carmen
author
Boscá, Lisardo
author
Fernández-Velasco, María
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Sociedad Española de Cardiología
funder
Unión Europea. Fondo Social Europeo (ESF/FSE)
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación La Caixa
2023-04-11T11:44:24Z
2023-04-11T11:44:24Z
2022-06
JACC Basic Transl Sci. 2022 May 18; 7(6):544-560
10.1016/j.jacbts.2022.01.009
2452-302X
JACC. Basic to translational science
35818504
http://hdl.handle.net/20.500.12105/15753
Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum-adenosine triphosphatase 2A down-regulation and Ca2+ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis.
eng
Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.
journal article
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Specialized Proresolving Mediators JACC Basic Transl Sci 2022.pdf
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https://repisalud.isciii.es/bitstreams/6a4e2539-2e6d-4804-8f6e-95ae7018a2b6/download
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Specialized Proresolving Mediators JACC Basic Transl Sci 2022.pdf.txt