2026-04-29T04:52:27Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157442024-09-21T10:51:18Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Wu, Joy Tzung-Yu author de la Hoz, Miguel Ángel Armengol author Kuo, Po-Chih author Paguio, Joseph Alexander author Yao, Jasper Seth author Dee, Edward Christopher author Yeung, Wesley author Jurado, Jerry author Moulick, Achintya author Milazzo, Carmelo author Peinado, Paloma author Villares, Paula author Cubillo, Antonio author Varona, José Felipe author Lee, Hyung-Chul author Estirado, Alberto author Castellano, José Maria author Celi, Leo Anthony author 2022-12 The unprecedented global crisis brought about by the COVID-19 pandemic has sparked numerous efforts to create predictive models for the detection and prognostication of SARS-CoV-2 infections with the goal of helping health systems allocate resources. Machine learning models, in particular, hold promise for their ability to leverage patient clinical information and medical images for prediction. However, most of the published COVID-19 prediction models thus far have little clinical utility due to methodological flaws and lack of appropriate validation. In this paper, we describe our methodology to develop and validate multi-modal models for COVID-19 mortality prediction using multi-center patient data. The models for COVID-19 mortality prediction were developed using retrospective data from Madrid, Spain (N = 2547) and were externally validated in patient cohorts from a community hospital in New Jersey, USA (N = 242) and an academic center in Seoul, Republic of Korea (N = 336). The models we developed performed differently across various clinical settings, underscoring the need for a guided strategy when employing machine learning for clinical decision-making. We demonstrated that using features from both the structured electronic health records and chest X-ray imaging data resulted in better 30-day mortality prediction performance across all three datasets (areas under the receiver operating characteristic curves: 0.85 (95% confidence interval: 0.83-0.87), 0.76 (0.70-0.82), and 0.95 (0.92-0.98)). We discuss the rationale for the decisions made at every step in developing the models and have made our code available to the research community. We employed the best machine learning practices for clinical model development. Our goal is to create a toolkit that would assist investigators and organizations in building multi-modal models for prediction, classification, and/or optimization. J Digit Imaging. 2022 Dec;35(6):1514-1529 http://hdl.handle.net/20.500.12105/15744 35789446 10.1007/s10278-022-00674-z 1618-727X Journal of digital imaging Developing and Validating Multi-Modal Models for Mortality Prediction in COVID-19 Patients: a Multi-center Retrospective Study.