2026-08-05T15:42:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157362024-09-21T11:33:02Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Tamayo, María
author
Martín-Nunes, Laura
author
Piedras, María José
author
Martin-Calvo, María
author
Martí-Morente, Daniel
author
Gil-Fernández, Marta
author
Gómez-Hurtado, Nieves
author
Moro, María Ángeles
author
Bosca, Lisardo
author
Fernández-Velasco, María
author
Delgado, Carmen
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Francisco de Vitoria University (España)
2023-04-03T12:15:46Z
2023-04-03T12:15:46Z
2022-05-12
Int J Mol Sci. 2022 May 12;23(10):5403
10.3390/ijms23105403
1422-0067
International journal of molecular sciences
35628213
http://hdl.handle.net/20.500.12105/15736
Adverse ventricular remodeling is the heart's response to damaging stimuli and is linked to heart failure and poor prognosis. Formyl-indolo [3,2-b] carbazole (FICZ) is an endogenous ligand for the aryl hydrocarbon receptor (AhR), through which it exerts pleiotropic effects including protection against inflammation, fibrosis, and oxidative stress. We evaluated the effect of AhR activation by FICZ on the adverse ventricular remodeling that occurs in the early phase of pressure overload in the murine heart induced by transverse aortic constriction (TAC). Cardiac structure and function were evaluated by cardiac magnetic resonance imaging (CMRI) before and 3 days after Sham or TAC surgery in mice treated with FICZ or with vehicle, and cardiac tissue was used for biochemical studies. CMRI analysis revealed that FICZ improved cardiac function and attenuated cardiac hypertrophy. These beneficial effects involved the inhibition of the hypertrophic calcineurin/NFAT pathway, transcriptional reduction in pro-fibrotic genes, and antioxidant effects mediated by the NRF2/NQO1 pathway. Overall, our findings provide new insight into the role of cardiac AhR signaling in the injured heart.
eng
The Aryl Hydrocarbon Receptor Ligand FICZ Improves Left Ventricular Remodeling and Cardiac Function at the Onset of Pressure Overload-Induced Heart Failure in Mice.
journal article
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The Aryl Hydrocarbon Receptor Int J Mol Sci 2022.pdf
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The Aryl Hydrocarbon Receptor Int J Mol Sci 2022.pdf.txt