2026-07-03T15:37:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157232024-09-27T08:02:54Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Rosina, Marco author Ceci, Veronica author Turchi, Riccardo author Chuan, Li author Borcherding, Nicholas author Sciarretta, Francesca author Sánchez-Díaz, María author Tortolici, Flavia author Karlinsey, Keaton author Chiurchiù, Valerio author Fuoco, Claudia author Giwa, Rocky author Field, Rachael L author Audano, Matteo author Arena, Simona author Palma, Alessandro author Riccio, Federica author Shamsi, Farnaz author Renzone, Giovanni author Verri, Martina author Crescenzi, Anna author Rizza, Salvatore author Faienza, Fiorella author Filomeni, Giuseppe author Kooijman, Sander author Rufini, Stefano author de Vries, Antoine A F author Scaloni, Andrea author Mitro, Nico author Tseng, Yu-Hua author Hidalgo, Andres author Zhou, Beiyan author Brestoff, Jonathan R author Aquilano, Katia author Lettieri-Barbato, Daniele author 2022-04-05 Recent findings have demonstrated that mitochondria can be transferred between cells to control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a large component of the cell volume and undergo reorganization to sustain thermogenesis, it remains unclear whether an intercellular mitochondrial transfer occurs in brown adipose tissue (BAT) and regulates adaptive thermogenesis. Herein, we demonstrated that thermogenically stressed brown adipocytes release extracellular vesicles (EVs) that contain oxidatively damaged mitochondrial parts to avoid failure of the thermogenic program. When re-uptaken by parental brown adipocytes, mitochondria-derived EVs reduced peroxisome proliferator-activated receptor-γ signaling and the levels of mitochondrial proteins, including UCP1. Their removal via the phagocytic activity of BAT-resident macrophages is instrumental in preserving BAT physiology. Depletion of macrophages in vivo causes the abnormal accumulation of extracellular mitochondrial vesicles in BAT, impairing the thermogenic response to cold exposure. These findings reveal a homeostatic role of tissue-resident macrophages in the mitochondrial quality control of BAT. Cell Metab. 2022 Apr 5;34(4):533-548.e12 10.1016/j.cmet.2022.02.016 1932-7420 Cell metabolism 35305295 http://hdl.handle.net/20.500.12105/15723 Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.