2026-04-29T00:59:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157172024-09-27T08:44:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Murugiah, Karthik
author
Chen, Lian
author
Dreyer, Rachel P
author
Bouras, Georgios
author
Safdar, Basmah
author
Khera, Rohan
author
Lu, Yuan
author
Spatz, Erica S
author
Ng, Vivian G
author
Gupta, Aakriti
author
Bueno, Hector
author
Tweet, Marysia S
author
Spertus, John A
author
Hayes, Sharonne N
author
Lansky, Alexandra
author
Krumholz, Harlan M
funder
NIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia y Tecnología (España)
funder
Fundación ProCNIC
2023-03-27T11:21:15Z
2023-03-27T11:21:15Z
2022
PLoS One. 2022 Mar 23;17(3):e0265624
http://hdl.handle.net/20.500.12105/15717
35320296
10.1371/journal.pone.0265624
1932-6203
PloS one
Data on health status outcomes after spontaneous coronary artery dissection (SCAD) are limited.
Using the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study we compared patients with SCAD and other acute myocardial infarction (AMI) at presentation (baseline), 1-month, and-12 months using standardized health status instruments. Among 3572 AMI patients ≤ 55 years, 67 had SCAD. SCAD patients were younger (median age (IQR) 45 (40.5-51) years vs. 48 (44-52) in other AMI, p = 0.003), more often female (92.5% vs. 66.6%), have college education (73.1% vs. 51.7%) and household income >$100,000 (43.3% vs. 17.7% (All p<0.001). SCAD patients at baseline had higher mean ± SD Short Form-12 [SF-12] physical component scores [PCS] (48.7±10.2 vs. 43.8±12.1, p<0.001) and mental component scores [MCS] (49.6±12.4 vs. 45.4±12.5, p = 0.008), and at 12-months [PCS (50.1±9.0 vs. 44.3±12.3, p<0.001) and MCS (53±10.1 vs 50.2±11.0, p = 0.045)]. The Euro-Quality of Life Scale [EQ-5D] VAS and EQ-5D index scores were similar at baseline, but higher at 12-months for SCAD (EQ-5D VAS: 82.2±10.2 vs. 72.3±21.0, p<0.001; EQ-5D index scores; 90.2±15.3 vs. 83.7±19.8, p = 0.012). SCAD patients had better baseline Seattle Angina Questionnaire [SAQ] physical limitation (88.8±20.1 vs. 81.2±25.4, p = 0.017). At 12-months SCAD patients had better physical limitation (98.0±8.5 vs. 91.4±18.8, p = 0.007), angina frequency (96.4±8.8 vs. 91.3±16.8, p = 0.018) and quality of life scores (80.7±14.7 vs 72.2±23.2, p = 0.005). Magnitude of change in health status from baseline to 12-months was not statistically different between the groups. After adjustment for time and comorbidities there remained no difference in most health status outcomes.
SCAD patients fare marginally better than other AMI patients on most health status instruments and have similar 12-month health status recovery. Better pre-event health status suggests a need to modify exercise prescriptions and cardiac rehabilitation protocols to better assist this physically active population to recover.
eng
Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience.
journal article
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Health status outcomes PLoS One 2022.pdf
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Health status outcomes PLoS One 2022.pdf.txt