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00925njm 22002777a 4500 dc Han, Lei author Wei, Xiaoyu author Liu, Chuanyu author Volpe, Giacomo author Zhuang, Zhenkun author Zou, Xuanxuan author Wang, Zhifeng author Pan, Taotao author Yuan, Yue author Zhang, Xiao author Fan, Peng author Guo, Pengcheng author Lai, Yiwei author Lei, Ying author Liu, Xingyuan author Yu, Feng author Shangguan, Shuncheng author Lai, Guangyao author Deng, Qiuting author Liu, Ya author Wu, Liang author Shi, Quan author Yu, Hao author Huang, Yunting author Cheng, Mengnan author Xu, Jiangshan author Liu, Yang author Wang, Mingyue author Wang, Chunqing author Zhang, Yuanhang author Xie, Duo author Yang, Yunzhi author Yu, Yeya author Zheng, Huiwen author Wei, Yanrong author Huang, Fubaoqian author Lei, Junjie author Huang, Waidong author Zhu, Zhiyong author Lu, Haorong author Wang, Bo author Wei, Xiaofeng author Chen, Fengzhen author Yang, Tao author Du, Wensi author Chen, Jing author Xu, Shibo author An, Juan author Ward, Carl author Wang, Zongren author Pei, Zhong author Wong, Chi-Wai author Liu, Xiaolei author Zhang, Huafeng author Liu, Mingyuan author Qin, Baoming author Schambach, Axel author Isern, Joan author Feng, Liqiang author Liu, Yan author Guo, Xiangyu author Liu, Zhen author Sun, Qiang author Maxwell, Patrick H author Barker, Nick author Muñoz-Cánoves, Pura author Gu, Ying author Mulder, Jan author Uhlen, Mathias author Tan, Tao author Liu, Shiping author Yang, Huanming author Wang, Jian author Hou, Yong author Xu, Xun author Esteban, Miguel A author Liu, Longqi author 2022-04 Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs. Nature. 2022 Apr;604(7907):723-731 http://hdl.handle.net/20.500.12105/15715 35418686 10.1038/s41586-022-04587-3 1476-4687 Nature Cell transcriptomic atlas of the non-human primate Macaca fascicularis.