2026-05-15T16:35:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157122025-03-24T13:50:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rodriguez-Muñoz, Diego
author
Sánchez, Ángela
author
Pérez-Benavente, Susana
author
Contreras-Jurado, Constanza
author
Montero-Pedrazuela, Ana
author
Toledo-Castillo, Marta
author
Gutiérrez-Hernández, María
author
Rodrigues-Díez, Raquel
author
Folgueira, Cintia
author
Briones, Ana M
author
Sabio, Guadalupe
author
Monedero-Cobeta, Ignacio
author
Chaves-Coira, Irene
author
Castejón, David
author
Fernández-Valle, Encarnación
author
Regadera, Javier
author
Bautista, José Manuel
author
Aranda, Ana
author
Alemany, Susana
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomédica en Red - CIBERONC (Cáncer)
funder
Instituto de Salud Carlos III
2023-03-27T10:37:14Z
2023-03-27T10:37:14Z
2022-04-08
Sci Adv. 2022 Apr 8;8(14):eabj7110
10.1126/sciadv.abj7110
2375-2548
Science advances
35385300
http://hdl.handle.net/20.500.12105/15712
The modulation of the host's metabolism to protect tissue from damage induces tolerance to infections increasing survival. Here, we examined the role of the thyroid hormones, key metabolic regulators, in the outcome of malaria. Hypothyroidism confers protection to experimental cerebral malaria by a disease tolerance mechanism. Hypothyroid mice display increased survival after infection with Plasmodium berghei ANKA, diminishing intracranial pressure and brain damage, without altering pathogen burden, blood-brain barrier disruption, or immune cell infiltration. This protection is reversed by treatment with a Sirtuin 1 inhibitor, while treatment of euthyroid mice with a Sirtuin 1 activator induces tolerance and reduces intracranial pressure and lethality. This indicates that thyroid hormones and Sirtuin 1 are previously unknown targets for cerebral malaria treatment, a major killer of children in endemic malaria areas.
eng
Hypothyroidism confers tolerance to cerebral malaria.
journal article
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https://repisalud.isciii.es/bitstreams/cf02a006-21fb-4d61-a66d-8767c25a4822/download
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c9ceab4ab21641202ed5922eec677e14
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Hypothyroidism confers tolerance Sci Adv 2022.pdf
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https://repisalud.isciii.es/bitstreams/5c5755f1-9f2f-4ecd-acef-3f4c5398b83b/download
File
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2f254199edf83262eb49ca5d56784c08
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Hypothyroidism confers tolerance Sci Adv 2022.pdf.txt