2026-04-29T23:03:56Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157122025-03-24T13:50:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Rodriguez-Muñoz, Diego author Sánchez, Ángela author Pérez-Benavente, Susana author Contreras-Jurado, Constanza author Montero-Pedrazuela, Ana author Toledo-Castillo, Marta author Gutiérrez-Hernández, María author Rodrigues-Díez, Raquel author Folgueira, Cintia author Briones, Ana M author Sabio, Guadalupe author Monedero-Cobeta, Ignacio author Chaves-Coira, Irene author Castejón, David author Fernández-Valle, Encarnación author Regadera, Javier author Bautista, José Manuel author Aranda, Ana author Alemany, Susana author 2022-04-08 The modulation of the host's metabolism to protect tissue from damage induces tolerance to infections increasing survival. Here, we examined the role of the thyroid hormones, key metabolic regulators, in the outcome of malaria. Hypothyroidism confers protection to experimental cerebral malaria by a disease tolerance mechanism. Hypothyroid mice display increased survival after infection with Plasmodium berghei ANKA, diminishing intracranial pressure and brain damage, without altering pathogen burden, blood-brain barrier disruption, or immune cell infiltration. This protection is reversed by treatment with a Sirtuin 1 inhibitor, while treatment of euthyroid mice with a Sirtuin 1 activator induces tolerance and reduces intracranial pressure and lethality. This indicates that thyroid hormones and Sirtuin 1 are previously unknown targets for cerebral malaria treatment, a major killer of children in endemic malaria areas. Sci Adv. 2022 Apr 8;8(14):eabj7110 10.1126/sciadv.abj7110 2375-2548 Science advances 35385300 http://hdl.handle.net/20.500.12105/15712 Hypothyroidism confers tolerance to cerebral malaria.