2026-04-29T07:25:14Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157112024-09-27T09:15:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Cecconi, Alberto author Navarrete, Gonzalo author Garcia-Guimaraes, Marcos author Vera, Alberto author Blanco-Dominguez, Rafael author Sanz-Garcia, Ancor author Lozano-Prieto, Marta author Lopez-Melgar, Beatriz author Rivero, Fernando author Martin, Pilar author Sanchez-Madrid, Francisco author de la Fuente, Hortensia author Jimenez-Borreguero, Luis Jesus author Alfonso, Fernando author 2022-03-30 Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4+ regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p. Sci Rep . 2022 Mar 30;12(1):5350 http://hdl.handle.net/20.500.12105/15711 35354890 10.1038/s41598-022-09383-7 2045-2322 Scientific reports Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.