2026-04-19T21:28:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/157082024-09-27T08:10:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Oller, Jorge
author
Gabandé-Rodríguez, Enrique
author
Roldan-Montero, Raquel
author
Ruiz-Rodríguez, María Jesús
author
Redondo, Juan Miguel
author
Martín-Ventura, José Luís
author
Mittelbrunn, María
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Comunidad de Madrid (España)
funder
Fundación La Caixa
funder
Ministerio de Ciencia e Innovación (España)
2023-03-27T09:47:29Z
2023-03-27T09:47:29Z
2022-04
Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):462-469
http://hdl.handle.net/20.500.12105/15708
35196876
10.1161/ATVBAHA.121.317346
1524-4636
Arteriosclerosis, thrombosis, and vascular biology
The goal of this study was to determine whether boosting mitochondrial respiration prevents the development of fatal aortic ruptures triggered by atherosclerosis and hypertension.
Ang-II (angiotensin-II) was infused in ApoE (Apolipoprotein E)-deficient mice fed with a western diet to induce acute aortic aneurysms and lethal ruptures.
We found decreased mitochondrial respiration and mitochondrial proteins in vascular smooth muscle cells from murine and human aortic aneurysms. Boosting NAD levels with nicotinamide riboside reduced the development of aortic aneurysms and sudden death by aortic ruptures.
Targetable vascular metabolism is a new clinical strategy to prevent fatal aortic ruptures and sudden death in patients with aortic aneurysms.
eng
Rewiring Vascular Metabolism Prevents Sudden Death due to Aortic Ruptures-Brief Report.
journal article
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URL
https://repisalud.isciii.es/bitstreams/99376f0e-5fc0-46ec-a219-bbe9bd929a55/download
File
MD5
07b71103b334a5770ba7b495ad4e80c5
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application/pdf
Rewiring Vascular Metabolism Arterioscler Thromb Vasc Biol 2022.pdf
URL
https://repisalud.isciii.es/bitstreams/5bdda18d-03d6-4486-8a61-5266d06cc8cd/download
File
MD5
138efd679712b831e934308f453e1a58
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text/plain
Rewiring Vascular Metabolism Arterioscler Thromb Vasc Biol 2022.pdf.txt