2026-04-19T21:28:17Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157082024-09-27T08:10:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Oller, Jorge author Gabandé-Rodríguez, Enrique author Roldan-Montero, Raquel author Ruiz-Rodríguez, María Jesús author Redondo, Juan Miguel author Martín-Ventura, José Luís author Mittelbrunn, María author 2022-04 The goal of this study was to determine whether boosting mitochondrial respiration prevents the development of fatal aortic ruptures triggered by atherosclerosis and hypertension. Ang-II (angiotensin-II) was infused in ApoE (Apolipoprotein E)-deficient mice fed with a western diet to induce acute aortic aneurysms and lethal ruptures. We found decreased mitochondrial respiration and mitochondrial proteins in vascular smooth muscle cells from murine and human aortic aneurysms. Boosting NAD levels with nicotinamide riboside reduced the development of aortic aneurysms and sudden death by aortic ruptures. Targetable vascular metabolism is a new clinical strategy to prevent fatal aortic ruptures and sudden death in patients with aortic aneurysms. Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):462-469 http://hdl.handle.net/20.500.12105/15708 35196876 10.1161/ATVBAHA.121.317346 1524-4636 Arteriosclerosis, thrombosis, and vascular biology Rewiring Vascular Metabolism Prevents Sudden Death due to Aortic Ruptures-Brief Report.