2026-05-22T00:20:10Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/157042024-09-27T09:47:14Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Monelli, Erika author Villacampa, Pilar author Zabala-Letona, Amaia author Martinez-Romero, Anabel author Llena, Judith author Beiroa, Daniel author Gouveia, Leonor author Chivite, Iñigo author Zagmutt, Sebastián author Gama-Perez, Pau author Osorio-Conles, Oscar author Muixi, Laia author Martinez-Gonzalez, Ainara author Castillo, Sandra D author Martín-Martín, Natalia author Castel, Pau author Valcarcel-Jimenez, Lorea author Garcia-Gonzalez, Irene author Villena, Josep A author Fernandez-Ruiz, Sonia author Serra, Dolors author Herrero, Laura author Benedito, Rui author Garcia-Roves, Pablo author Vidal, Josep author Cohen, Paul author Nogueiras, Rubén author Claret, Marc author Carracedo, Arkaitz author Graupera, Mariona author 2022-03 Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of angiogenesis upon WAT expansion, a process that is impaired in obesity. However, the molecular mechanisms underlying the crosstalk between ECs and adipocytes remain poorly understood. Here, we show that local production of polyamines in ECs stimulates adipocyte lipolysis and regulates WAT homeostasis in mice. We promote enhanced cell-autonomous angiogenesis by deleting Pten in the murine endothelium. Endothelial Pten loss leads to a WAT-selective phenotype, characterized by reduced body weight and adiposity in pathophysiological conditions. This phenotype stems from enhanced fatty acid β-oxidation in ECs concomitant with a paracrine lipolytic action on adipocytes, accounting for reduced adiposity. Combined analysis of murine models, isolated ECs and human specimens reveals that WAT lipolysis is mediated by mTORC1-dependent production of polyamines by ECs. Our results indicate that angiocrine metabolic signals are important for WAT homeostasis and organismal metabolism. Nat Metab. 2022 Mar;4(3):327-343 10.1038/s42255-022-00544-6 2522-5812 Nature metabolism 35288722 http://hdl.handle.net/20.500.12105/15704 Angiocrine polyamine production regulates adiposity.