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oai:repisalud.isciii.es:20.500.12105/156982024-09-27T10:01:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Llorente, Vicente author Velarde, Pedro author Desco, Manuel author Gómez-Gaviro, María Victoria author 2022-09-26 Neural stem cells (NSCs) are self-renewing, multipotent cells which give rise to all components of the central nervous system (CNS) during embryogenesis, but also activate in response to injury and disease and maintain a certain level of neurogenic activity throughout adulthood. This activity takes place in specialized regions of the brain, the neurovascular niches, whose main role is to control the behaviour of the CNS. In adult mammals, two main "canonical" niches have been described: The subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus. This review discusses our current understanding of the neural stem cells and their canonical niches, as well as their structure, behaviours, and role in neural disease. Cells. 2022 Sep 26;11(19):3002 http://hdl.handle.net/20.500.12105/15698 36230964 10.3390/cells11193002 2073-4409 Cells Current Understanding of the Neural Stem Cell Niches.