2026-07-15T15:00:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/156942024-09-27T08:31:00Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hidalgo, Andres
author
Libby, Peter
author
Soehnlein, Oliver
author
Aramburu, Iker Valle
author
Papayannopoulos, Venizelos
author
Silvestre-Roig, Carlos
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
Swedish Heart-Lung Foundation
funder
Fondation Leducq
funder
NIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos)
funder
Medical Research Council (Reino Unido)
funder
European Molecular Biology Organization
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea
2023-03-23T09:23:53Z
2023-03-23T09:23:53Z
2022-10-21
Cardiovasc Res. 2022 Oct 21;118(13):2737-2753
10.1093/cvr/cvab329
1755-3245
Cardiovascular research
34648022
http://hdl.handle.net/20.500.12105/15694
At the frontline of the host defence response, neutrophil antimicrobial functions have adapted to combat infections and injuries of different origins and magnitude. The release of web-like DNA structures named neutrophil extracellular traps (NETs) constitutes an important mechanism by which neutrophils prevent pathogen dissemination or deal with microorganisms of a bigger size. At the same time, nuclear and granule proteins with microbicidal activity bind to these DNA structures promoting the elimination of entrapped pathogens. However, these toxic properties may produce unwanted effects in the host, when neutrophils uncontrollably release NETs upon persistent inflammation. As a consequence, NET accumulation can produce vessel occlusion, tissue damage, and prolonged inflammation associated with the progression and exacerbation of multiple pathologic conditions. This review outlines recent advances in understanding the mechanisms of NET release and functions in sterile disease. We also discuss mechanisms of physiological regulation and the importance of neutrophil heterogeneity in NET formation and composition.
eng
Neutrophil extracellular traps: from physiology to pathology.
review
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URL
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File
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Neutrophil extracellular traps Cardiovasc Res 2022.pdf
URL
https://repisalud.isciii.es/bitstreams/fa04ac6e-bc34-4208-8b8e-9562d1c3ef94/download
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Neutrophil extracellular traps Cardiovasc Res 2022.pdf.txt