2026-04-22T12:15:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/156912024-09-27T09:41:54Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lamanna-Rama, Nicolás
author
Romero-Miguel, Diego
author
Desco, Manuel
author
Soto-Montenegro, Maria Luisa
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Plan Nacional de Drogas (España)
funder
Fundación Alicia Koplowitz
funder
Comunidad de Madrid (España)
funder
Unión Europea. Fondo Social Europeo (ESF/FSE)
funder
Instituto de Investigación Sanitaria Gregorio Marañón
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-03-23T08:55:40Z
2023-03-23T08:55:40Z
2022-02-10
Antioxidants (Basel). 2022 Feb 10;11(2):353
2076-3921
http://hdl.handle.net/20.500.12105/15691
35204235
10.3390/antiox11020353
Antioxidants (Basel, Switzerland)
Curcumin is a polyphenol extracted from the rhizome of the turmeric plant. Beyond its common use as a culinary spice in Eastern Asia, curcumin has been proposed as a therapeutic compound due to its antioxidant, anti-inflammatory and neuroprotective properties. Thus, its efficacy has been evaluated in various inflammatory-based psychiatric disorders, such as schizophrenia, depression, or autism. Our aim is to review those preclinical and clinical studies carried out in psychiatric disorders whose therapeutic approach has involved the use of curcumin and, therefore, to discern the possible positive effect of curcumin in these disorders. Preclinical studies and completed clinical trials of curcumin for psychiatric disorders published from January 2005 to October 2021 were identified through searching relevant databases until 31st October 2021. Sixty-five preclinical studies and 15 clinical trials and open-label studies were selected. Results showed a bias toward studies in depression and, to a lesser extent, schizophrenia. In all disorders, the results were positive in reducing psychiatric deficits. Despite the considerable number of beneficial outcomes reported, the small number of trials and the heterogeneity of protocols make it difficult to draw solid conclusions about the real potency of curcumin in psychiatric disorders.
eng
An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders.
review
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URL
https://repisalud.isciii.es/bitstreams/06b0fd89-73f2-46d5-bba5-41fe4da5c08c/download
File
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An Update on the Exploratory Antioxidants Basel 2022.pdf
URL
https://repisalud.isciii.es/bitstreams/c92b505b-e9c1-48a4-9d69-a5408716ceec/download
File
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An Update on the Exploratory Antioxidants Basel 2022.pdf.txt