2026-04-29T02:37:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/156842024-09-27T09:56:48Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Díaz-Chamorro, Selene
author
Garrido-Jiménez, Sergio
author
Barrera-López, Juan Francisco
author
Mateos-Quirós, Clara María
author
Cumplido-Laso, Guadalupe
author
Lorenzo, María Jesús
author
Román, Ángel Carlos
author
Bernardo, Edgar
author
Sabio, Guadalupe
author
Carvajal-González, José María
author
Centeno, Francisco
funder
Government of Extremadura (España)
funder
Ministerio de Economía (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2023-03-22T12:14:37Z
2023-03-22T12:14:37Z
2021
Front Cell Dev Biol. 2022 Jan 17;9:708844
2296-634X
http://hdl.handle.net/20.500.12105/15684
35111744
10.3389/fcell.2021.708844
Frontiers in cell and developmental biology
IL6 is an essential cytokine in metabolism regulation and for intercommunication among different organs and tissues. IL6 produced by different tissues has different functions and therefore it is very important to understand the mechanism of its expression in adipose tissue. In this work we demonstrated that IL6 expression in mouse preadipocytes, like in human, is partially dependent on Wnt5a and JNK. Using mouse preadipocytes lacking each one of the p38 SAPK family members, we have shown that IL6 expression is also p38γ and p38δ dependent. In fact, the lack of some of these two kinases increases IL6 expression without altering that of Wnt5a. Moreover, we show that the absence of p38δ promotes greater ERK1/2 phosphorylation in a MEK1/2 independent manner, and that this increased ERK1/2 phosphorylation state is contributing to the higher IL6 expression in p38δ-/- preadipocytes. These results suggest a new crosstalk between two MAPK signaling pathway, p38δ and ERK1/2, where p38δ modulates the phosphorylation state of ERK1/2.
eng
Title: p38δ Regulates IL6 Expression Modulating ERK Phosphorylation in Preadipocytes.
journal article
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URL
https://repisalud.isciii.es/bitstreams/e46104f5-a45c-4832-823d-3a79a165fcfa/download
File
MD5
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application/pdf
Title p38δ Regulates IL6 Expression Front Cell Dev Biol 2022.pdf
URL
https://repisalud.isciii.es/bitstreams/62aa603d-a452-436e-8f43-09559e9229a3/download
File
MD5
0ad810fdf1936cbe4f45d1ab331a0868
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text/plain
Title p38δ Regulates IL6 Expression Front Cell Dev Biol 2022.pdf.txt