2026-04-19T07:39:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/156742024-09-27T09:56:54Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hong, Xiaotong
author
Isern, Joan
author
Campanario, Silvia
author
Perdiguero, Eusebio
author
Ramírez-Pardo, Ignacio
author
Segalés, Jessica
author
Hernansanz-Agustín, Pablo
author
Curtabbi, Andrea
author
Deryagin, Oleg
author
Pollán, Angela
author
González-Reyes, José A
author
Villalba, José M
author
Sandri, Marco
author
Serrano, Antonio L
author
Enriquez, Jose Antonio
author
Muñoz-Cánoves, Pura
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Fundación La Marató TV3
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Regional Government of Andalusia (España)
funder
Unión Europea. Comisión Europea. H2020
funder
Marie Curie
2023-03-17T14:37:08Z
2023-03-17T14:37:08Z
2022-09-01
Cell Stem Cell. 2022 Sep 1;29(9):1298-1314.e10
http://hdl.handle.net/20.500.12105/15674
35998641
10.1016/j.stem.2022.07.009
1875-9777
Cell stem cell
Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential for the successful regenerative capacity of satellite cells. The loss of mitochondrial fission in satellite cells-due to aging or genetic impairment-deregulates the mitochondrial electron transport chain (ETC), leading to inefficient oxidative phosphorylation (OXPHOS) metabolism and mitophagy and increased oxidative stress. This state results in muscle regenerative failure, which is caused by the reduced proliferation and functional loss of satellite cells. Regenerative functions can be restored in fission-impaired or aged satellite cells by the re-establishment of mitochondrial dynamics (by activating fission or preventing fusion), OXPHOS, or mitophagy. Thus, mitochondrial shape and physical networking controls stem cell regenerative functions by regulating metabolism and proteostasis. As mitochondrial fission occurs less frequently in the satellite cells in older humans, our findings have implications for regeneration therapies in sarcopenia.
eng
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy.
journal article
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Mitochondrial dynamics maintain Cell Stem Cell 2022.pdf
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Mitochondrial dynamics maintain Cell Stem Cell 2022.pdf.txt