2026-04-18T02:13:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/156512024-11-28T20:24:44Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16967col_20.500.12105_16969col_20.500.12105_16977
Repisalud
author
Garcia-Lunar, Ines
author
van der Ploeg, Hidde P
author
Fernández Alvira, Juan Miguel
author
van Nassau, Femke
author
Castellano Vázquez, Jose Maria
author
van der Beek, Allard J
author
Rossello, Xavier
author
Fernández-Ortiz, Antonio
author
Coffeng, Jennifer
author
van Dongen, Johanna M
author
Mendiguren, Jose Maria
author
Ibáñez, Borja
author
van Mechelen, Willem
author
Fuster, Valentin
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
AstraZeneca
funder
Banco Santander
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Fundación ProCNIC
2023-03-16T13:08:19Z
2023-03-16T13:08:19Z
2022-10-11
Eur Heart J. 2022 Oct 11;43(38):3732-3745
http://hdl.handle.net/20.500.13003/18575
http://hdl.handle.net/20.500.12105/15651
35869885
10.1093/eurheartj/ehac378
1522-9645
European heart journal
2-s2.0-8513973895
833581400001
L638563889
Aims: To investigate the effectiveness of a 3-year worksite lifestyle intervention on cardiovascular metrics and to study whether outcomes are influenced by baseline subclinical atherosclerosis (SA) by non-invasive imaging. Methods and results: A randomized controlled trial was performed to compare a lifestyle intervention with standard of care in asymptomatic middle-aged subjects, stratified by SA. The intervention consisted of nine motivational interviews during the first year, followed by three further sessions between Years 1 and 3. The primary outcome was the change in a pre-specified adaptation of the Fuster-BEWAT score (Blood pressure, Exercise, Weight, Alimentation, and Tobacco) between baseline and follow-up Years 1-3. A total of 1020 participants (mean age 50 ± 4 years) were enrolled, of whom 510 were randomly assigned to the intervention and 510 to the control group. The baseline adapted Fuster-BEWAT score was 16.2 ± 3.7 points in the intervention group and 16.5 ± 3.5 points in the control group. At Year 1, the score improved significantly in intervention participants compared with controls [estimate 0.83 (95% CI 0.52-1.15) points]. However, intervention effectiveness decreased to non-significant levels at Year 3 [0.24 (95% CI -0.10 to 0.59) points]. Over the 3-year period, the intervention was effective in participants having low baseline SA [0.61 (95% CI 0.30-0.93) points] but not in those with high baseline SA [0.19 (95% CI -0.26 to 0.64) points]. Conclusion: In middle-aged asymptomatic adults, a lifestyle intervention was associated with a significant improvement in cardiovascular health and behavioural metrics. The effect attenuated after 1 year as the intensity of the intervention was reduced. Trial registration: ClinicalTrials.gov (NCT02561065).
eng
Effects of a comprehensive lifestyle intervention on cardiovascular health: the TANSNIP-PESA trial
research article
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Effects of a comprehensive lifestyle Eur Heart J 2022.pdf
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Effects of a comprehensive lifestyle Eur Heart J 2022.pdf.txt