2026-04-18T02:13:23Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/156512024-11-28T20:24:44Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16967col_20.500.12105_16969col_20.500.12105_16977

00925njm 22002777a 4500 dc Garcia-Lunar, Ines author van der Ploeg, Hidde P author Fernández Alvira, Juan Miguel author van Nassau, Femke author Castellano Vázquez, Jose Maria author van der Beek, Allard J author Rossello, Xavier author Fernández-Ortiz, Antonio author Coffeng, Jennifer author van Dongen, Johanna M author Mendiguren, Jose Maria author Ibáñez, Borja author van Mechelen, Willem author Fuster, Valentin author 2022-10-11 Aims: To investigate the effectiveness of a 3-year worksite lifestyle intervention on cardiovascular metrics and to study whether outcomes are influenced by baseline subclinical atherosclerosis (SA) by non-invasive imaging. Methods and results: A randomized controlled trial was performed to compare a lifestyle intervention with standard of care in asymptomatic middle-aged subjects, stratified by SA. The intervention consisted of nine motivational interviews during the first year, followed by three further sessions between Years 1 and 3. The primary outcome was the change in a pre-specified adaptation of the Fuster-BEWAT score (Blood pressure, Exercise, Weight, Alimentation, and Tobacco) between baseline and follow-up Years 1-3. A total of 1020 participants (mean age 50 ± 4 years) were enrolled, of whom 510 were randomly assigned to the intervention and 510 to the control group. The baseline adapted Fuster-BEWAT score was 16.2 ± 3.7 points in the intervention group and 16.5 ± 3.5 points in the control group. At Year 1, the score improved significantly in intervention participants compared with controls [estimate 0.83 (95% CI 0.52-1.15) points]. However, intervention effectiveness decreased to non-significant levels at Year 3 [0.24 (95% CI -0.10 to 0.59) points]. Over the 3-year period, the intervention was effective in participants having low baseline SA [0.61 (95% CI 0.30-0.93) points] but not in those with high baseline SA [0.19 (95% CI -0.26 to 0.64) points]. Conclusion: In middle-aged asymptomatic adults, a lifestyle intervention was associated with a significant improvement in cardiovascular health and behavioural metrics. The effect attenuated after 1 year as the intensity of the intervention was reduced. Trial registration: ClinicalTrials.gov (NCT02561065). Eur Heart J. 2022 Oct 11;43(38):3732-3745 http://hdl.handle.net/20.500.13003/18575 http://hdl.handle.net/20.500.12105/15651 35869885 10.1093/eurheartj/ehac378 1522-9645 European heart journal 2-s2.0-8513973895 833581400001 L638563889 Effects of a comprehensive lifestyle intervention on cardiovascular health: the TANSNIP-PESA trial