2026-07-21T07:35:45Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/156452024-05-27T19:32:32Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Petrus, Paul author Smith, Jacob G author Koronowski, Kevin B author Chen, Siwei author Sato, Tomoki author Greco, Carolina M author Mortimer, Thomas author Welz, Patrick-Simon author Zinna, Valentina M author Shimaji, Kohei author Cervantes, Marlene author Punzo, Daniela author Baldi, Pierre author Muñoz-Cánoves, Pura author Sassone-Corsi, Paolo author Benitah, Salvador Aznar author 2022-07 Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in part, by temporal coordination of metabolism. Here, we characterize the extent to which clocks in different organs control systemic metabolic rhythms, an area that remains largely unexplored. We analyzed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1. Having functional hepatic and muscle clocks can only drive a minority (13%) of systemic metabolic rhythms. Conversely, limiting Bmal1 expression to the central pacemaker in the brain restores rhythms to 57% of circulatory metabolites. Rhythmic feeding imposed on clockless mice resulted in a similar rescue, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals. Sci Adv. 2022 Jul;8(26):eabo2896 10.1126/sciadv.abo2896 2375-2548 Science advances 35767612 http://hdl.handle.net/20.500.12105/15645 The central clock suffices to drive the majority of circulatory metabolic rhythms.