2026-04-30T03:50:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/156362024-09-27T08:09:16Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Soto-Montenegro, Mª Luisa
author
García-Vázquez, Verónica
author
Lamanna-Rama, Nicolás
author
López-Montoya, Gonzalo
author
Desco, Manuel
author
Ambrosio, Emilio
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Mapfre
funder
Fundación Alicia Koplowitz
funder
Plan Nacional de Drogas (España)
funder
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
funder
RETICS-Transtornos Adictivos (RTA-ISCIII) (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea
funder
Instituto de Investigación Sanitaria Gregorio Marañón
funder
Fundación ProCNIC
funder
National University of Distance Education (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-03-16T09:16:06Z
2023-03-16T09:16:06Z
2022-03-17
Sci Rep. 2022 Mar 17;12(1):4643
10.1038/s41598-022-08698-9
2045-2322
Scientific reports
35301397
http://hdl.handle.net/20.500.12105/15636
Vulnerability to addiction may be given by the individual's risk of developing an addiction during their lifetime. A challenge in the neurobiology of drug addiction is understanding why some people become addicted to drugs. Here, we used positron emission tomography (PET) and statistical parametric mapping (SPM) to evaluate changes in brain glucose metabolism in response to chronic morphine self-administration (MSA) in two rat strains with different vulnerability to drug abuse, Lewis (LEW) and Fischer 344 (F344). Four groups of animals were trained to self-administer morphine or saline for 15 days. 2-deoxy-2-[18F]-fluoro-D-glucose (FDG)-PET studies were performed on the last day of MSA (acquisition phase) and after 15 days of withdrawal. PET data were analyzed using SPM12. LEW-animals self-administered more morphine injections per session than F344-animals. We found significant brain metabolic differences between LEW and F344 strains in the cortex, hypothalamus, brainstem, and cerebellum. In addition, the different brain metabolic patterns observed after the MSA study between these rat strains indicate differences in the efficiency of neural substrates to translate the drug effects, which could explain the differences in predisposition to morphine abuse between one individual and another. These findings have important implications for the use of these rat strains in translational morphine and opiate research.
eng
Neuroimaging reveals distinct brain glucose metabolism patterns associated with morphine consumption in Lewis and Fischer 344 rat strains.
journal article
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https://repisalud.isciii.es/bitstreams/4c7920e1-1d65-4c18-bf67-1c5c96aa58a1/download
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Neuroimaging reveals distinct Sci Rep 2022.pdf
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https://repisalud.isciii.es/bitstreams/8b65deef-af4b-46f1-9285-53fc93380add/download
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Neuroimaging reveals distinct Sci Rep 2022.pdf.txt