2026-05-06T16:09:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/156342025-03-27T10:23:14Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Garcia-Garcia, Maria author Sánchez-Perales, Sara author Jarabo, Patricia author Calvo, Enrique author Huyton, Trevor author Fu, Liran author Ng, Sheung Chun author Sotodosos-Alonso, Laura author Vazquez, Jesus author Casas-Tinto, Sergio author Görlich, Dirk author Echarri, Asier author del Pozo, Miguel Angel author 2022-03-04 Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an essential step for mechanotransduction. However, how mechanical forces regulate the nuclear import process is not understood. Here, we identify a highly mechanoresponsive nuclear transport receptor (NTR), Importin-7 (Imp7), that drives the nuclear import of YAP, a key regulator of mechanotransduction pathways. Unexpectedly, YAP governs the mechanoresponse of Imp7 by forming a YAP/Imp7 complex that responds to mechanical cues through the Hippo kinases MST1/2. Furthermore, YAP behaves as a dominant cargo of Imp7, restricting the Imp7 binding and the nuclear translocation of other Imp7 cargoes such as Smad3 and Erk2. Thus, the nuclear import process is an additional regulatory layer indirectly regulated by mechanical cues, which activate a preferential Imp7 cargo, YAP, which competes out other cargoes, resulting in signaling crosstalk. Nat Commun. 2022 Mar 4;13(1):1174 10.1038/s41467-022-28693-y 2041-1723 Nature communications 35246520 http://hdl.handle.net/20.500.12105/15634 Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP