2026-07-21T14:26:47Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/155842025-06-17T08:09:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616

00925njm 22002777a 4500 dc Iskrov, Georgi G author Stefanov, Rumen S author López-Bastida, Julio author Linertová, Renata author Oliva-Moreno, Juan author Serrano-Aguilar, Pedro author BURQOL-RD Research Network author Posada De la Paz, Manuel author Hens Pérez, Manuel author Abaitua-Borda, Ignacio author 2015-03 Objective: The aim of this study was to determine the economic burden from a societal perspective and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) in Bulgaria. Materials and methods: We conducted a cross-sectional study of 33 patients with CF and 17 caregivers from Bulgaria. Data on socio-demographic characteristics, health resource utilisation, informal care, labor productivity losses and HRQOL were collected from questionnaires completed by patients or their caregivers. HRQOL was evaluated with the EuroQol 5-domain (EQ-5D-3L) questionnaire. Results: Median annual costs of CF in Bulgaria were € 24 152 per patient in 2012 as a reference year. Median annual costs for children were found to be significantly higher than those for adults - € 31 945 vs. € 15 714 (p = 0.012). This outcome came from statistically significant differences in costs for main informal carer (p < 0.001) and costs for other informal carers (p = 0.022). As a single cost item, drugs had the biggest monetary impact. Median annual drug costs were € 13 059. Bulgarian CF patients showed low HRQOL results - 50 median VAS score and 0.592 median health utilities. A quarter of patients even rated their health state as worse than death. Conclusion: CF patients from Eastern Europe remain a vulnerable population with risk factors for worse health outcomes. Our study provided a state-of-the art analysis that facilitates the elaboration, adoption and application of targeted public health policies to tackle CF-related problems at national and European level. Folia Med (Plovdiv). 2015 Jan-Mar;57(1):56-64. 10.1515/folmed-2015-0020 0204-8043 Folia medica 26431096 http://hdl.handle.net/20.500.12105/15584 Cystic fibrosis Health-related quality of life Costs and cost analysis Economic burden Bulgaria Economic Burden And Health-Related Quality Of Life Of Patients With Cystic Fibrosis In Bulgaria