2026-06-14T05:18:27Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/155632024-09-27T08:58:36Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Wculek, Stefanie K
author
Dunphy, Gillian
author
Heras-Murillo, Ignacio
author
Mastrangelo, Annalaura
author
Sancho, David
funder
Fundación La Caixa
funder
European Molecular Biology Organization
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Agencia Estatal de Investigación (España)
funder
Comunidad de Madrid (España)
funder
Atresmedia
funder
Fundación Banco Santander
funder
Fundación La Marató TV3
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
2023-03-02T16:22:33Z
2023-03-02T16:22:33Z
2022-03
Cell Mol Immunol. 2022 Mar;19(3):384-408
10.1038/s41423-021-00791-9
2042-0226
Cellular & molecular immunology
34876704
http://hdl.handle.net/20.500.12105/15563
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural components. The emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune cells. Macrophages are embryo- or adult bone marrow-derived leukocytes that are key for healthy tissue homeostasis but can also contribute to pathologies such as metabolic syndrome, atherosclerosis, fibrosis or cancer. Macrophage metabolism has largely been studied in vitro. However, different organs contain diverse macrophage populations that specialize in distinct and often tissue-specific functions. This context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their particular microenvironment and conditions their response in pathological conditions. Here, we outline current knowledge on the metabolic requirements and adaptations of macrophages located in tissues during homeostasis and selected diseases.
eng
Metabolism of tissue macrophages in homeostasis and pathology.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8670163d-c7b9-4667-b478-7b99df607ff4/download
File
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application/pdf
Metabolism of tissue macrophages_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/465278bf-7e32-40f3-bc6c-c9dc81044cd4/download
File
MD5
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text/plain
Metabolism of tissue macrophages_2022.pdf.txt