2026-07-24T06:28:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/155502025-05-07T10:36:07Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19616col_20.500.12105_16990
Repisalud
author
Gambera, Stefano
author
Abarrategi, Ander
author
Rodriguez-Milla, Miguel A
author
Mulero, Francisca
author
Menéndez, Sofía T
author
Rodriguez, Rene
author
Navarro, Samuel
author
Garcia-Castro, Javier
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERONC (Cáncer)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
2023-02-28T10:45:56Z
2023-02-28T10:45:56Z
2018-10
Stem Cells. 2018 Oct;36(10):1487-1500.
10.1002/stem.2869
1549-4918
Stem cells (Dayton, Ohio)
30001480
http://hdl.handle.net/20.500.12105/15550
Osteosarcoma (OS) is a highly aggressive bone tumor that usually arises intramedullary at the extremities of long bones. Due to the fact that the peak of incidence is in the growth spurt of adolescence, the specific anatomical location, and the heterogeneity of cells, it is believed that osteosarcomagenesis is a process associated with bone development. Different studies in murine models showed that the tumor-initiating cell in OS could be an uncommitted mesenchymal stem cell (MSC) developing in a specific bone microenvironment. However, only a few studies have reported transgene-induced human MSCs transformation and mostly obtained undifferentiated sarcomas. In our study, we demonstrate that activator protein 1 family members induce osteosarcomagenesis in immortalized hMSC. c-JUN or c-JUN/c-FOS overexpression act as tumorigenic factors generating OS with fibroblastic or pleomorphic osteoblastic phenotypes, respectively. Stem Cells 2018;36:1487-1500.
eng
Mesenchymal stem cells
Osteosarcoma
p53
Rbc-JUN
c-FOS
Role of Activator Protein-1 Complex on the Phenotype of Human Osteosarcomas Generated from Mesenchymal Stem Cells
research article
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RoleActivatorProtein-1Complex_2018.pdf
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https://repisalud.isciii.es/bitstreams/7015e9c9-334a-4977-b54d-ac79c88ea8a0/download
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RoleActivatorProtein-1Complex_2018.pdf.txt