2026-05-22T00:40:20Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/154792024-09-27T23:47:59Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Falcon, A
author
Cuevas, Maria Teresa
author
Rodriguez-Frandsen, A
author
Reyes, Noelia
author
Pozo Sanchez, Francisco
author
Moreno, Silvia
author
Ledesma, Juan
author
Martínez-Alarcón, J
author
Nieto, A
author
Casas Flecha, Inmaculada
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias)
funder
Ministerio de Ciencia e Innovación (España)
2023-02-09T18:01:42Z
2023-02-09T18:01:42Z
2015-08
J Gen Virol. 2015 Aug;96(8):2074-2078.
10.1099/vir.0.000165
1465-2099
The Journal of general virology
25918237
http://hdl.handle.net/20.500.12105/15479
Influenza epidemics affect all age groups, although children, the elderly and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are in apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32 bp deletion in the CCR5 gene) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-Δ32 and evaluated its correlation with patient mortality. CCR5-Δ32 patients (17.4%) showed a higher mortality rate than WT individuals (4.7%; P = 0.021), which indicates that CCR5-Δ32 patients are at higher risk than the normal population of a fatal outcome in influenza infection.
eng
CCR5 deficiency predisposes to fatal outcome in influenza virus infection
journal article
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CCR5DeficiencyPredisposesFatal_2015.pdf
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Supplementary_CCR5DeficiencyPredisposesFatal_2015.pdf
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CCR5DeficiencyPredisposesFatal_2015.pdf.txt
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Supplementary_CCR5DeficiencyPredisposesFatal_2015.pdf.txt